Document Detail

The relationship between infant lung function and the risk of wheeze in the preschool years.
MedLine Citation:
PMID:  20848581     Owner:  NLM     Status:  MEDLINE    
RATIONALE: There is evidence that perinatal lung development predicts childhood wheeze. However, very few studies have examined whether preschool wheeze is associated with lower premorbid lung function in early infancy, and as yet there is no information relating atopic and non-atopic preschool wheeze to early lung development.
OBJECTIVE: To examine the association between premorbid infant lung function and preschool wheeze, and to explore associations with atopic and non-atopic wheeze phenotypes.
METHODS: Infant lung function was measured in 147 healthy term infants aged 5-14 weeks. Rapid thoracoabdominal compression was performed during tidal breathing and at raised volume to measure maximal expiratory flow at functional residual capacity (V' max FRC) and forced expiratory volume in 0.4 sec (FEV(0.4)). Atopic status was determined by skin prick testing at 3 years and wheeze ascertained from parental questionnaires (1 and 3 years).
MEASUREMENTS AND MAIN RESULTS: Lower early infancy V' max FRC was associated with wheeze in both the first and third years of life (P=0.002 and 0.006, respectively). Lower early infancy FEV(0.4) was associated with wheeze in the first year (P=0.03). Compared to non-atopic children who did not wheeze, non-atopic children who wheezed in their third year of life had lower FEV(0.4) (P=0.02), while FEV(0.4) values of atopic children who wheezed were not significantly different (P=0.4).
CONCLUSIONS: Lower premorbid infant lung function was present in infants who subsequently wheezed during the first and third years of life. Lower FEV(0.4) in early infancy was associated with non-atopic wheeze but not atopic wheeze at 3 years of age.
K C Pike; M J Rose-Zerilli; E Caffrey Osvald; H M Inskip; K M Godfrey; S R Crozier; G Roberts; J B Clough; J W Holloway; J S Lucas;
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-16
Journal Detail:
Title:  Pediatric pulmonology     Volume:  46     ISSN:  1099-0496     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  2011-04-29     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  75-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley-Liss, Inc.
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MeSH Terms
Asthma / epidemiology*,  physiopathology
Birth Weight
Child, Preschool
Great Britain / epidemiology
Lung / growth & development,  physiology*
Prospective Studies
Respiratory Function Tests
Respiratory Sounds / physiopathology*
Retrospective Studies
Skin Tests
Grant Support
MC_UP_A620_1017//Medical Research Council; RG/07/009/23120//British Heart Foundation; SP/02/003/14542//British Heart Foundation; //British Heart Foundation; //Medical Research Council

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