Document Detail

The relationship between induction of peroxisomal beta-oxidation and long-chain fatty acid composition in rat liver.
MedLine Citation:
PMID:  8364516     Owner:  NLM     Status:  MEDLINE    
The long-chain fatty acid composition in rat liver, by which peroxisomal beta-oxidation system was induced, was analyzed in vitro and in vivo. In primary culture of hepatocytes, treatment with 0.4 mM clofibrate or long-chain fatty acids caused an increase in the peroxisomal beta-oxidation activity, in addition the oleic acid [18:1(n-9)] content in the cells was increased two-fold by addition of very long-chain fatty acids to the culture medium, but clofibrate had no effect. A two-fold of increase in 18:1(n-9) content was observed in the hepatic subcellular fractions from rats fed a diet containing 0.25% clofibric acid. The ratio of cis-vaccenic acid [18:1(n-7)] to total 18:1 content decreased by more than half compared with control in clofibric acid treated liver. The level of 18:1(n-7) was not changed in all experiments. It is suggested that perturbation of C-18 chain length fatty acids occurs in peroxisomal beta-oxidation induced liver.
H Kawano; A Shibahara; K Yamamoto; T Hama; G Kajimoto
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  16     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-10-04     Completed Date:  1993-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  608-10     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
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MeSH Terms
Body Composition / physiology
Clofibrate / pharmacology
Fatty Acids / metabolism*
Liver / drug effects,  metabolism*
Microbodies / metabolism*
Rats, Wistar
Subcellular Fractions / drug effects,  metabolism
Reg. No./Substance:
0/Fatty Acids; 637-07-0/Clofibrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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