| The relationship between induction of peroxisomal beta-oxidation and long-chain fatty acid composition in rat liver. | |
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MedLine Citation:
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PMID: 8364516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The long-chain fatty acid composition in rat liver, by which peroxisomal beta-oxidation system was induced, was analyzed in vitro and in vivo. In primary culture of hepatocytes, treatment with 0.4 mM clofibrate or long-chain fatty acids caused an increase in the peroxisomal beta-oxidation activity, in addition the oleic acid [18:1(n-9)] content in the cells was increased two-fold by addition of very long-chain fatty acids to the culture medium, but clofibrate had no effect. A two-fold of increase in 18:1(n-9) content was observed in the hepatic subcellular fractions from rats fed a diet containing 0.25% clofibric acid. The ratio of cis-vaccenic acid [18:1(n-7)] to total 18:1 content decreased by more than half compared with control in clofibric acid treated liver. The level of 18:1(n-7) was not changed in all experiments. It is suggested that perturbation of C-18 chain length fatty acids occurs in peroxisomal beta-oxidation induced liver. |
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Authors:
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H Kawano; A Shibahara; K Yamamoto; T Hama; G Kajimoto |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Biological & pharmaceutical bulletin Volume: 16 ISSN: 0918-6158 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 1993 Jun |
Date Detail:
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Created Date: 1993-10-04 Completed Date: 1993-10-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: JAPAN |
Other Details:
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Languages: eng Pagination: 608-10 Citation Subset: IM |
Affiliation:
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Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Composition / physiology Clofibrate / pharmacology Fatty Acids / metabolism* Liver / drug effects, metabolism* Male Microbodies / metabolism* Oxidation-Reduction Rats Rats, Wistar Subcellular Fractions / drug effects, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 637-07-0/Clofibrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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