Document Detail

A relationship between increased peritoneal leptin levels and infertility in endometriosis.
MedLine Citation:
PMID:  18958774     Owner:  NLM     Status:  MEDLINE    
Endometriosis is a common, complex and chronic disease related to ectopic implantation and growth of endometrial tissue that may manifest by pelvic pain, and accounts for over 20% of all cases of infertility in women. Endometriosis may be associated with increased levels of leptin in peritoneal fluid. However, the association of leptin with infertility has not been definitely documented. Therefore, the aim of the present study was to search for a relationship between concentrations of peritoneal-fluid leptin and patients' clinical status. The study included 56 patients being diagnosed for infertility and/or pelvic pain. Peritoneal fluid was aspirated during routine laparoscopic examination. Concentrations of leptin in peritoneal fluid were evaluated by a specific enzyme-linked immunosorbent assay. The results revealed that the levels of peritoneal-fluid leptin did not correlate with different stage of endometriosis. However, they correlated with body mass index. Leptin levels were significantly higher in infertile patients than in patients with pelvic pain (p = 0.0023 by Mann-Whitney U test or p = 0.0045 by analysis of variance). It may suggest that increased leptin levels in the peritoneal fluid may play a role in pathogenesis of infertility.
Ewa Barcz; Lukasz Milewski; Dariusz Radomski; Piotr Dziunycz; Paweł Kamiński; Piotr I Roszkowski; Jacek Malejczyk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  24     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-29     Completed Date:  2009-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  526-30     Citation Subset:  IM    
I Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.
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MeSH Terms
Ascitic Fluid / chemistry,  metabolism*,  pathology
Body Mass Index
Endometriosis / complications,  metabolism*,  pathology
Infertility, Female / etiology,  metabolism*
Leptin / analysis,  metabolism*,  physiology
Pelvic Pain / etiology,  metabolism
Peritoneal Diseases / complications,  metabolism*,  pathology
Up-Regulation / physiology
Reg. No./Substance:

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