Document Detail


The relationship between glycogen synthesis, biofilm formation and virulence in salmonella enteritidis.
MedLine Citation:
PMID:  11004396     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Salmonella enteritidis accumulated large quantities of intracellular polysaccharide when grown in unrestricted nutrient conditions. Dense, abundant cytoplasmic granules were observed by electron microscopy in sections stained by the periodic acid-chlorite technique, indicating that the polysaccharide was of the glycogen type. When biofilm-producing S. enteritidis was pre-incubated in media containing increasing levels of glucose concentration, the levels of both cytoplasmic glycogen and biofilm rose correlatively to a point where a ceiling effect was observed. Studies carried out with activators and inhibitors of glycogen biosynthesis confirmed that biofilm was formed from glycogen cell stores. On the other hand, the virulence of the biofilm-producing strain in infected chickens increased proportionally to the amount of stored glycogen, suggesting a possible role of the glycogen depot in the virulence of S. enteritidis.
Authors:
M A Bonafonte; C Solano; B Sesma; M Alvarez; L Montuenga; D García-Ros; C Gamazo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEMS microbiology letters     Volume:  191     ISSN:  0378-1097     ISO Abbreviation:  FEMS Microbiol. Lett.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-12-01     Completed Date:  2000-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7705721     Medline TA:  FEMS Microbiol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  31-6     Citation Subset:  IM    
Affiliation:
Departamento de Microbiologia, Universidad de Navarra, Pamplona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biofilms / growth & development*
Chickens
Glucose / metabolism
Glycogen / biosynthesis*
Microscopy, Electron
Poultry Diseases / microbiology
Salmonella Infections, Animal / microbiology
Salmonella enteritidis / growth & development,  metabolism*,  pathogenicity*
Virulence
Chemical
Reg. No./Substance:
50-99-7/Glucose; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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