Document Detail


The relationship between gastroesophageal reflux and apnea in infants.
MedLine Citation:
PMID:  10969254     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the prevalence and relationship between apnea and gastroesophageal reflux (GER) among infants with apparent life-threatening events. METHODS: We evaluated 67 infants of ages up to 6 months who had an idiopathic apparent life-threatening event as determined by polysomnography and pH monitoring. RESULTS: No reflux (pH < 4 for more than 6 seconds) was evident in 32 infants. Fourteen others had such prolonged reflux that the relationship between apnea and reflux could not be evaluated. The 21 remaining infants who had episodes of apnea and reflux constituted the study group. In 81% of the apneic episodes, no relationship to GER was noted. Apnea preceded reflux in 93.6% of the episodes, and only 6.4% of the apneic episodes followed reflux. When apnea preceded reflux, the apnea was obstructive in 66.8% of episodes and mixed in 33.2%. Central apnea was not recorded preceding reflux. CONCLUSIONS: Episodes of apnea were seldom associated with GER. However, in those instances when apnea and reflux were associated, the predominant sequence of events was obstructive apnea and to a lesser extent mixed apnea followed by reflux.
Authors:
N Arad-Cohen; A Cohen; E Tirosh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  137     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-03     Completed Date:  2000-10-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  321-6     Citation Subset:  AIM; IM    
Affiliation:
Jacobo Lichtman Apnea Investigation Unit, Department of Pediatrics, Bnai Zion Medical Center, Technion, Israel.
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MeSH Terms
Descriptor/Qualifier:
Female
Gastroesophageal Reflux / complications*
Humans
Hydrogen-Ion Concentration
Infant
Male
Polysomnography
Risk Factors
Sleep Apnea Syndromes / complications*
Sleep Apnea, Central / complications
Sleep Apnea, Obstructive / complications
Statistics, Nonparametric
Time Factors
Comments/Corrections
Comment In:
J Pediatr. 2001 Sep;139(3):470   [PMID:  11562633 ]
J Pediatr. 2000 Sep;137(3):298-300   [PMID:  10969250 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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