| Relationship between free T4 levels and postnatal steroid therapy in preterm infants. | |
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MedLine Citation:
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PMID: 19419509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Transient hypothyroxinemia is the most common thyroid dysfunction in preterm infants. Hypothalamic-pituitary-thyroid immaturity and non-thyroidal illness contribute to its etiology. The aim of the present study was therefore to determine the relationship between thyroid hormone status and early postnatal steroid therapy in preterm infants. METHODS: A prospective study of premature infants born at <28 weeks of gestation between July 2001 and June 2007 was conducted. Selective postnatal steroid (dexamethasone) therapy was used in lung disease treatment if the infants needed high mean airway pressure-assisted ventilation and supplemental oxygen at 2 weeks of age. Free T4 (FT4) and thyroid-stimulating hormone (TSH) levels were assessed at 2 weeks after birth. Blood samples in eight infants were available after starting steroid therapy. Infants receiving steroids (steroid (+); n= 8) were compared to those not receiving steroids (steroid (-); n= 73). RESULTS: The demographic data were not significantly different between the two groups. The neonatal illnesses and drug use were also not significantly different between the groups. The steroid (+) group had significantly lower FT4 and TSH levels at 2 weeks after birth than the steroid (-) group. The increase in FT4 levels after steroid withdrawal was greater than that during the same period in the steroid (-) patients. CONCLUSION: Even if it cannot be excluded that reduced FT4 and TSH concentrations are caused by non-thyroidal illness, the present study suggests that postnatal steroid treatment reduces the FT4 and TSH levels in premature infants born at <28 weeks of gestation. |
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Authors:
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Hirokazu Arai; Ryoji Goto; Takefumi Matsuda; Tsutomu Takahashi |
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Publication Detail:
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Type: Journal Article Date: 2009-03-20 |
Journal Detail:
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Title: Pediatrics international : official journal of the Japan Pediatric Society Volume: 51 ISSN: 1442-200X ISO Abbreviation: Pediatr Int Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-07-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100886002 Medline TA: Pediatr Int Country: Australia |
Other Details:
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Languages: eng Pagination: 800-3 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Akita Red Cross Hospital, Akita, Japan. arahiro@med.akita-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents
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adverse effects*,
therapeutic use Dexamethasone / adverse effects*, therapeutic use Female Gestational Age Humans Hypothyroidism / blood, chemically induced*, diagnosis* Infant, Newborn Infant, Premature, Diseases / blood*, drug therapy* Infant, Small for Gestational Age* Infant, Very Low Birth Weight* Intensive Care Units, Neonatal Male Prospective Studies Reference Values Thyrotropin / blood Thyroxine / blood* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 50-02-2/Dexamethasone; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin |
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