Document Detail

The relationship between flow-mediated dilatation of the brachial artery and intima-media thickness of the carotid artery to Framingham risk scores in older African Americans.
MedLine Citation:
PMID:  20021528     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to investigate the relationship of flow-mediated dilatation and intima-media thickness (IMT) with coronary risk in African Americans (AAs). Endothelial dysfunction and IMT of carotid arteries are considered early steps in atherosclerotic disease process and have been used as surrogate markers of subclinical atherosclerosis. Data were collected on 106 AAs with a mean age of 64.0+/-6.6 years. Carotid artery IMT was measured with B-mode ultrasonography, as was brachial artery diameter at rest, during reactive hyperemia, and after nitroglycerin. Percent change in flow-mediated dilatation (%FMD) was defined as 100x(diameter during reactive hyperemia - resting diameter)/resting diameter. Percent change in nitroglycerin-mediated dilatation (%NMD) was defined as 100x(diameter with nitroglycerin-resting diameter)/resting diameter. The Framingham 10-year risk score (FRS) was calculated for each patient using the National Cholesterol Education Program (NCEP) risk score calculator and participants were categorized into 3 groups with FRS as <10%, 10% to 20%, and >20%. Thirty-eight participants had risk scores <10%, 26 had 10% to 20%, and 42 >20%. There was a significant inverse relation between %FMD and FRS (P<.0001) and between %NMD and FRS (P<.001). IMT was not statistically different among the risk groups. Endothelial dysfunction assessed by FMD significantly correlates inversely with FRS in AAs. FMD, an index of arterial compliance, appears to be a sensitive and reliable index of cardiovascular disease.
John Kwagyan; Saifudin Hussein; Shichen Xu; Muluemebet Ketete; Abid R Maqbool; Robert H Schneider; Otelio S Randall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical hypertension (Greenwich, Conn.)     Volume:  11     ISSN:  1751-7176     ISO Abbreviation:  J Clin Hypertens (Greenwich)     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-21     Completed Date:  2010-03-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888554     Medline TA:  J Clin Hypertens (Greenwich)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  713-9     Citation Subset:  IM    
Department of Medicine/Cardiology, Howard University Hospital, 2041 Georgia Avenue NW, Washington, DC 20060, USA.
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MeSH Terms
African Americans / statistics & numerical data*
Age Factors
Aged, 80 and over
Analysis of Variance
Brachial Artery / pathology*,  ultrasonography
Cardiovascular Diseases / epidemiology,  ethnology*,  pathology
Carotid Artery, Common / pathology*,  ultrasonography
Cerebrovascular Circulation
Dilatation, Pathologic / ethnology
Endothelium, Vascular / pathology
Middle Aged
Multivariate Analysis
Regression Analysis
Risk Assessment / methods
Statistics as Topic
Tunica Intima / pathology*,  ultrasonography
Tunica Media / pathology*,  ultrasonography
United States / epidemiology

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