| The relationship between extravascular lung water and oxygenation in three patients with influenza A (H1N1)-induced respiratory failure. | |
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MedLine Citation:
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PMID: 20949325 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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This case series reports the correlation between extravascular lung water (EVLW) and the partial arterial oxygen pressure/fractional inspiratory oxygen (PaO(2)/FiO(2)) ratio in three patients with severe influenza A (H1N1)-induced respiratory failure. All patients suffered from grave hypoxia (PaO(2), 26-42 mmHg) and were mechanically ventilated using biphasic airway pressure (PEEP, 12-15 mmHg; FiO(2), 0.8-1) in combination with prone positioning at 12 hourly intervals. All patients were monitored using the PICCO system for 8-11 days. During mechanical ventilation, a total of 62 simultaneous determinations of the PaO(2)/FiO(2) ratio and EVLW were performed. A significant correlation between EVLW and the PaO(2)/FiO(2) ratio (Spearman-rho correlation coefficient, -0.852; p < 0.001) was observed. In all patients, a decrease in EVLW was accompanied by an improvement in oxygenation. Serum lactate dehydrogenase levels were elevated in all patients and significantly correlated with EVLW during the intensive care unit stay (Spearman-rho correlation coefficient, 0.786; p < 0.001). In conclusion, EVLW seems increased in patients with severe H1N1-induced respiratory failure and appears to be closely correlated with impairments of oxygenatory function. |
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Authors:
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Walter R Hasibeder; Martin W Dünser; Milad Halabi; Gabriele Brinninger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-20 |
Journal Detail:
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Title: Wiener klinische Wochenschrift Volume: 122 ISSN: 1613-7671 ISO Abbreviation: Wien. Klin. Wochenschr. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 21620870R Medline TA: Wien Klin Wochenschr Country: Austria |
Other Details:
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Languages: eng Pagination: 637-40 Citation Subset: IM |
Affiliation:
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Department of Anesthesia and Critical Care Medicine, Hospital of the Barmherzigen Schwestern, Ried im Innkreis, Austria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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