Document Detail

The relationship between the extracellular matrix and the angiogenesis and metastasis of laryngeal carcinoma.
MedLine Citation:
PMID:  18984970     Owner:  NLM     Status:  MEDLINE    
AIMS: We studied the relationships between the growth, metastasis and angiogenesis of laryngeal carcinoma and extracellular matrix protein-1 (ECM1) and hyaluronan (HA). METHODS: Thirty-three cases of benign and malignant laryngeal tumors were included. Using immunohistochemical staining, we examined the expression of ECM1 and HA in tumors and metastatic lymph nodes and correlated it with counts of microvessel density. RESULTS: The expression of ECM1 (p = 0.004) and HA (p = 0.036) was significantly different between benign and malignant tumors. The expression of ECM1 was strongly associated with microvessel density (Spearman's rho = 0.513, p = 0.017), with the strongest expression present within caner nests. With respect to HA, expression was significantly associated with more advanced clinical TNM stage (Spearman's rho = 0.521, p = 0.015). The link was stronger in cases where metastasis or recurrence occurred than in those without complication (p = 0.014). No significant relationship was found between ECM1 and HA expression among malignant samples (Spearman's rho = 0.383, p = 0.087). CONCLUSIONS: ECM1 has a high association with the growth, metastasis and angiogenesis of laryngeal carcinoma. An increased level of HA expression was related to the process of laryngeal carcinogenesis. Specifically, carcinoma cells with high levels of HA secretion had a higher potential for metastasis. No significant relative expression of ECM1 and HA was found.
Zhao Han; Guo-Jing Lin; Fang-Lu Chi; Shu-Yi Wang; Jian-Min Huang; Hong-Jian Liu; Lu-Rong Zhang
Publication Detail:
Type:  Journal Article     Date:  2008-11-04
Journal Detail:
Title:  ORL; journal for oto-rhino-laryngology and its related specialties     Volume:  70     ISSN:  1423-0275     ISO Abbreviation:  ORL J. Otorhinolaryngol. Relat. Spec.     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-05     Completed Date:  2009-02-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0334721     Medline TA:  ORL J Otorhinolaryngol Relat Spec     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  352-8     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Department of Otorhinolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, PR China.
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MeSH Terms
Biopsy, Needle
Carcinoma, Squamous Cell / mortality,  pathology,  secondary*
Cohort Studies
Extracellular Matrix Proteins / genetics,  metabolism*
Laryngeal Neoplasms / mortality,  pathology*
Lymph Nodes / pathology
Middle Aged
Neoplasm Invasiveness / pathology
Neoplasm Metastasis
Neoplasm Staging
Neovascularization, Pathologic / pathology*
Risk Assessment
Sampling Studies
Sensitivity and Specificity
Statistics, Nonparametric
Survival Analysis
Tumor Markers, Biological / metabolism*
Reg. No./Substance:
0/ECM1 protein, human; 0/Extracellular Matrix Proteins; 0/Tumor Markers, Biological

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