| The relationship between p21/waf1 expression patterns and cell proliferation during the tumorigenesis of the bronchus. | |
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MedLine Citation:
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PMID: 10402234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Each developmental stage in the process towards bronchial squamous cell carcinoma (normal epithelium, squamous metaplasia and early stage squamous cell carcinoma including in situ carcinoma) was examined for p21/waf1 protein expression and cell proliferation using MIB1. P21/waf1 immunoreactivity was classified into four patterns: predominantly cytoplasmic staining, exclusively nuclear staining, both nuclear and cytoplasmic staining and negative. The cases with predominantly cytoplasmic staining showed suppression of cell proliferation. Most cases with either negative or exclusively nuclear staining revealed high cell proliferation. The simultaneous evaluation of p21/waf1 and cell proliferation is valuable for clinical determination of the high risk for malignant transformation. |
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Authors:
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T Hirano; M Kakihana; K Tsuji; H Shibanuma; T Ohira; N Ikeda; N Kawate; C Konaka; Y Ebihara; H Kato |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of oncology Volume: 15 ISSN: 1019-6439 ISO Abbreviation: Int. J. Oncol. Publication Date: 1999 Aug |
Date Detail:
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Created Date: 1999-08-20 Completed Date: 1999-08-20 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9306042 Medline TA: Int J Oncol Country: GREECE |
Other Details:
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Languages: eng Pagination: 253-8 Citation Subset: IM |
Affiliation:
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Department of Surgery, Tokyo Medical University, Shinjuku-ku, Tokyo 160-0023, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blotting, Western Bronchial Neoplasms / metabolism*, pathology Carcinoma, Squamous Cell / metabolism*, pathology Cell Division / physiology Cyclin-Dependent Kinase Inhibitor p21 Cyclins / biosynthesis* Cytoplasm / metabolism Enzyme Inhibitors / metabolism* Epithelial Cells / metabolism, pathology Humans Immunohistochemistry Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/CDKN1A protein, human; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/Cyclins; 0/Enzyme Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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