| The relationship between exhaled nitric oxide measured with an off-line method and airway reversible obstruction in Japanese adults with asthma. | |
| | |
MedLine Citation:
|
PMID: 17259808 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Exhaled nitric oxide (eNO) is a useful marker of eosinophilic airway inflammation in asthma patients. There is no study to show the relationship between the eNO measured by using an off-line method and the degree of reversibility of airflow limitation in Japanese asthma patients. We sought to investigate the relationship between the eNO level measured by using an off-line method and the degree of reversibility of bronchial constriction in Japanese asthma patients. METHODS: The study population comprised 97 asthma patients in our outpatient clinic with some patients in both groups who received inhaled corticosteroid treatment. We measured eNO levels, forced expiratory volume in one second (FEV1) before and after treatment, reversible airway obstruction (DeltaFEV1) after inhalation of bronchodilator, and other parameters. RESULTS: eNO was significantly correlated with peripheral blood eosinophil counts in asthma patients (in steroid-naïve asthma patients, r=0.544, p<0.0001; in asthma patients treated with inhaled corticosteroid, r=0.463, p=0.026), and subjects with severe eosinophilia in sputum showed high levels of eNO (mild eosinophilia versus severe, p=0.0152). Among patients with obstructive impairment, eNO levels were correlated with DeltaFEV1 regardless of whether patients received (r=0.527, p=0.0435) or did not receive (r=0.64, p = 0.0056) inhaled corticosteroid. In subjects with normal pulmonary function, there was no significant relationship between eNO and DeltaFEV1 with or without inhaled corticosteroid. CONCLUSIONS: In patients with obstructive impairment, eNO reflects the degree of reversible airflow limitation. In subjects with normal pulmonary function, eNO may facilitate the diagnosis and management of asthma, rather than indicate reversible bronchial obstruction. eNO measurement by off-line methods is applicable as a potential tool for the diagnosis of asthma and management of asthma patients. |
| | |
Authors:
|
Takahiro Tsuburai; Naomi Tsurikisawa; Masami Taniguchi; Sonoko Morita; Emiko Ono; Chiyako Oshikata; Mamoru Ohtomo; Yuji Maeda; Kunihiko Ikehara; Kazuo Akiyama |
Related Documents
:
|
15354678 - Epidemiology, clinical and economic burden, and natural history of chronic obstructive ... 8342888 - Trial of standard versus modified expiration to achieve end-of-test spirometry criteria. 22118318 - Assessment of body composition using bioelectrical impedance analysis in prader-willi s... 373438 - Identification of the high-risk asthmatic patient. experience with 39 patients undergoi... 3352008 - Useful icp monitoring with subarachnoid catheter method in severe head injuries. 9677018 - Mast cells in bronchiectasis. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-01-29 |
Journal Detail:
|
Title: Allergology international : official journal of the Japanese Society of Allergology Volume: 56 ISSN: 1323-8930 ISO Abbreviation: Allergol Int Publication Date: 2007 Mar |
Date Detail:
|
Created Date: 2007-02-23 Completed Date: 2007-06-05 Revised Date: 2008-03-06 |
Medline Journal Info:
|
Nlm Unique ID: 9616296 Medline TA: Allergol Int Country: Japan |
Other Details:
|
Languages: eng Pagination: 37-43 Citation Subset: IM |
Affiliation:
|
Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan. t-tuburai@Sagamihara-hosp.gr.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Cortex Hormones
/
therapeutic use Aged Airway Obstruction / drug therapy*, etiology Asthma / complications, drug therapy*, physiopathology* Breath Tests / methods Bronchodilator Agents / therapeutic use Eosinophilia / etiology, immunology Exhalation Female Forced Expiratory Volume Humans Male Middle Aged Nitric Oxide / analysis, metabolism* Sputum / cytology |
| Chemical | |
Reg. No./Substance:
|
0/Adrenal Cortex Hormones; 0/Bronchodilator Agents; 10102-43-9/Nitric Oxide |
| Comments/Corrections | |
Erratum In:
|
Allergol Int. 2007 Sep;56(3):317 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The distinctive effects of acute and chronic psychological stress on airway inflammation in a murine...
Next Document: Serum concentrations of eosinophil cationic protein and eosinophils of patients with Kimura's diseas...