| The relationship between exertional heat illness, exertional rhabdomyolysis, and malignant hyperthermia. | |
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MedLine Citation:
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PMID: 19617585 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exertional heat illness, exertional rhabdomyolysis, and malignant hyperthermia (MH) are complex syndromes with similar pathophysiology. All three are hypermetabolic states that include high demand for adenosine triphosphate, accelerated oxidative, chemical, and mechanical stress of muscle, and uncontrolled increase in intracellular calcium. Although there are no controlled clinical studies to support a relationship, there is evidence to suggest an association between unexpected heat/exercise intolerance and MH susceptibility. There are multiple case reports and a small number of clinical studies that have used in vitro muscle contracture testing and/or genetic testing to make the association. However, such methodology is problematic in that these tests are validated for clinical MH in association with anesthesia, and not for exertional heat illness or exertional rhabdomyolysis. Nevertheless, these relationships may have implications for some MH-susceptible patients and their capacity to exercise, as well as for clinicians treating and anesthetizing patients with histories of unexplained exertional heat and exercise illnesses. |
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Authors:
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John F Capacchione; Sheila M Muldoon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-07-17 |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 109 ISSN: 1526-7598 ISO Abbreviation: Anesth. Analg. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-18 Completed Date: 2009-10-01 Revised Date: 2010-04-02 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: United States |
Other Details:
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Languages: eng Pagination: 1065-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA. jcapacchione@usuhs.mil |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia
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adverse effects* Evidence-Based Medicine Exercise Tolerance Heat Stress Disorders / complications* Humans Malignant Hyperthermia / diagnosis, etiology* Physical Exertion* Practice Guidelines as Topic Rhabdomyolysis / complications* Risk Assessment Risk Factors |
| Comments/Corrections | |
Comment In:
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Anesth Analg. 2010 Apr;110(4):1241; author reply 1241
[PMID:
20357163
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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