Document Detail


The relationship between estimated glomerular filtration rate and thyroid function: an observational study.
MedLine Citation:
PMID:  18753427     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Estimated glomerular filtration rate (eGFR) is now routinely reported by most National Health Service laboratories. There are many limitations when interpreting eGFR: thyroid dysfunction is not widely recognized as being one of these. METHODS: We extracted from the pathology computer system results of all patients with hypothyroidism and hyperthyroidism who also had serum creatinine measured. We also extracted creatinine data on euthyroid patients. eGFR was calculated using the simplified Modification of Diet in Renal Disease Study equation. RESULTS: The median eGFRs of the hypothyroid, euthyroid and hyperthyroid patients were 64, 77 and 107 mL/min/1.73 m(2), respectively; all groups were significantly different from each other (P < 0.001). CONCLUSION: Thyroid dysfunction is associated with significant alterations in eGFR and actual GFR.
Authors:
Anne Woodward; Steven McCann; Mohammad Al-Jubouri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  45     ISSN:  0004-5632     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-28     Completed Date:  2008-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  515-7     Citation Subset:  IM    
Affiliation:
Department of Clinical Biochemistry, Whiston Hospital, Warrington Road, Merseyside, UK.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Creatinine / blood
Female
Glomerular Filtration Rate*
Humans
Hyperthyroidism / blood
Hypothyroidism / blood
Kidney Diseases / blood
Male
Middle Aged
Thyroid Function Tests / methods*
Thyroid Gland / metabolism,  pathology*
Chemical
Reg. No./Substance:
60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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