Document Detail


The relationship between endogenous cortisol, blood micronutrients, and neutrophil function in postparturient Holstein cows.
MedLine Citation:
PMID:  14658729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neutrophil function, blood micronutrients, and cortisol concentrations were measured in 43 clinically healthy postparturient Holstein cows. Estimated 305-day mature equivalent milk production and neutrophil function were related to results of the blood micronutrient concentrations and neutrophil function tests. Cattle had low to normal zinc concentrations; normal to high selenium, vitamin E, and cortisol concentrations; and normal copper concentrations. Blood selenium (P = .03) and zinc (P = .027) concentrations were both significant predictors of neutrophil adhesion, and selenium (P < .001) was a significant predictor of neutrophil cytochrome C reduction (superoxide production). Fourteen of 20 (70%) cattle with blood selenium concentrations > 300 ng/mL had neutrophil adhesion, and 15 of 20 (75%) had cytochrome C reduction above the mean value for this group. There was also a significant correlation (r = 0.331; P = .037) between cytochrome C reduction and estimated milk production. These findings suggest that neutrophils from postparturient dairy cows with higher blood concentrations of selenium have greater potential to kill microbes, and that cattle with greater superoxide production may have higher milk production.
Authors:
Christopher K Cebra; Jerry R Heidel; Russell O Crisman; Bernadette V Stang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  17     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    2003 Nov-Dec
Date Detail:
Created Date:  2003-12-08     Completed Date:  2004-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  902-7     Citation Subset:  IM    
Affiliation:
Department of Clinical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA. christopher.cebra@oregonstate.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle / blood*
Cell Adhesion / physiology
Copper / blood
Cytochromes c / metabolism
Female
Hydrocortisone / blood
Lactation / blood
Micronutrients / blood*
Milk / secretion
Neutrophils / metabolism,  physiology*
Postpartum Period / blood*
Selenium / blood
Statistics, Nonparametric
Superoxides / metabolism
Zinc / blood
Chemical
Reg. No./Substance:
0/Micronutrients; 11062-77-4/Superoxides; 50-23-7/Hydrocortisone; 7440-50-8/Copper; 7440-66-6/Zinc; 7782-49-2/Selenium; 9007-43-6/Cytochromes c

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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