Document Detail


The relationship between drug input and mean residence time in the body.
MedLine Citation:
PMID:  3828487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relationship between the mean residence time after oral dosing or any other non-instantaneous mode of administration (MRTni) was explored by a series of computer simulations. MRTni was calculated from the ratio of AUMC to AUC (where AUC and AUMC are the zeroth and first statistical moments, respectively, of the drug concentration-time curve). A continuous linear relationship between MRTni and 1/ka or 1/k0 was observed. In the 'flip-flop' case where ka less than K (where K is the last elimination rate constant), the extrapolation from t* to infinity (where t* is the last observed plasma concentration) should be done using ka instead of K. If K is used, underestimated values of MRTni will be obtained. The findings from this investigation have practical application in the design and pharmacokinetic evaluation of novel sustained-release dosage forms.
Authors:
M Bialer; Z M Look; B M Silber; A Yacobi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biopharmaceutics & drug disposition     Volume:  7     ISSN:  0142-2782     ISO Abbreviation:  Biopharm Drug Dispos     Publication Date:    1986 Nov-Dec
Date Detail:
Created Date:  1987-05-12     Completed Date:  1987-05-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7911226     Medline TA:  Biopharm Drug Dispos     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  577-83     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Computer Simulation
Humans
Intestinal Absorption
Kinetics
Mathematics
Metabolic Clearance Rate
Models, Biological
Pharmaceutical Preparations / metabolism*
Chemical
Reg. No./Substance:
0/Pharmaceutical Preparations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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