| The relationship between drug input and mean residence time in the body. | |
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MedLine Citation:
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PMID: 3828487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relationship between the mean residence time after oral dosing or any other non-instantaneous mode of administration (MRTni) was explored by a series of computer simulations. MRTni was calculated from the ratio of AUMC to AUC (where AUC and AUMC are the zeroth and first statistical moments, respectively, of the drug concentration-time curve). A continuous linear relationship between MRTni and 1/ka or 1/k0 was observed. In the 'flip-flop' case where ka less than K (where K is the last elimination rate constant), the extrapolation from t* to infinity (where t* is the last observed plasma concentration) should be done using ka instead of K. If K is used, underestimated values of MRTni will be obtained. The findings from this investigation have practical application in the design and pharmacokinetic evaluation of novel sustained-release dosage forms. |
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Authors:
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M Bialer; Z M Look; B M Silber; A Yacobi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biopharmaceutics & drug disposition Volume: 7 ISSN: 0142-2782 ISO Abbreviation: Biopharm Drug Dispos Publication Date: 1986 Nov-Dec |
Date Detail:
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Created Date: 1987-05-12 Completed Date: 1987-05-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7911226 Medline TA: Biopharm Drug Dispos Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 577-83 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Computer Simulation Humans Intestinal Absorption Kinetics Mathematics Metabolic Clearance Rate Models, Biological Pharmaceutical Preparations / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Pharmaceutical Preparations |
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