Document Detail

The relationship between distress and the development of a primary immune response to a novel antigen.
MedLine Citation:
PMID:  14651948     Owner:  NLM     Status:  MEDLINE    
Forty-five medical students were recruited to examine the effects of distress on the development of an immune response to the novel antigen, keyhole limpet hemocyanin (KLH). The subjects' level of distress was manipulated by immunizing them either at the time of an important viva voce examination (n=22) or during examination-free term time (n=23). This manipulation increased variance amongst the subjects, but the emphasis in this research was on individual distress as a predictor of immune function. In the group as a whole, the likelihood of developing DTH skin responses to KLH was reduced in the more distressed subjects (r=-.45; p=.002), independently of a number of behavioral (e.g., sleep disturbance) and demographic (e.g., sex) variables. Proliferation of T cells against KLH in vitro and the development of anti-KLH IgG antibodies were not related to levels of distress. Thus, cellular, rather than humoral, immune responses in vivo appear susceptible to the influence of distress. This immunization model provides the opportunity to further dissect the basis of these stress-immune pathways.
Alison Smith; Ute Vollmer-Conna; Barbara Bennett; Denis Wakefield; Ian Hickie; Andrew Lloyd
Related Documents :
6519958 - Attempts to use thiabendazole to improve the immune response in dexamethasone-treated o...
843528 - Antibody synthesis stimulation by vitamin a in chickens.
1497478 - Effects of cigarette smoke on the antibody responses to thymic independent antigens fro...
25290628 - Processing of viral antigens and presentation to class ii-restricted t cells.
9949328 - Engagement of the b-cell antigen receptor by antigen negatively regulates ige productio...
6798568 - Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associat...
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain, behavior, and immunity     Volume:  18     ISSN:  0889-1591     ISO Abbreviation:  Brain Behav. Immun.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-03-01     Revised Date:  2013-11-14    
Medline Journal Info:
Nlm Unique ID:  8800478     Medline TA:  Brain Behav Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  65-75     Citation Subset:  IM    
School of Psychology, University of Western Sydney, Locked Bag 1797, Penrith South, DC NSW 1797, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antibody Formation / physiology*
Hemocyanin / immunology*
Immunity, Cellular / physiology*
Immunization / psychology
Neuroimmunomodulation / physiology
Reference Values
Stress, Psychological / immunology*
Reg. No./Substance:
9013-72-3/Hemocyanin; FV4Y0JO2CX/keyhole-limpet hemocyanin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of acute stress, relaxation, and a neurogenic inflammatory stimulus on interleukin-6 in huma...
Next Document:  Enhancement of antibody response by one-trial conditioning: contrasting results using different anti...