Document Detail


The relationship between diffusion anisotropy and time of onset after stroke.
MedLine Citation:
PMID:  16552424     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diffusion anisotropy changes in stroke lesions less than 24 h after onset have been reported to be elevated, decreased, or both. To address these mixed findings, we sought to characterize temporal changes of diffusion anisotropy by analyzing anatomically distinct ischemic white matter (WM) regions at 3 time phases within the first 34 h of ischemic stroke onset in 26 stroke patients (2 to 5 h, N=7; 7 to 14 h, N=11; 18 to 34 h, N=8). Mean diffusivity (Trace/3 apparent diffusion coefficient (ADC)), fractional anisotropy (FA), and T2-weighted signal intensity were measured for major and subcortical WM in lesions defined by a >or=30% drop in Trace/3 ADC. Major WM tract lesions with mean decreases of approximately 40% in relative (r) Trace/3 ADC showed an increased rFA of 1.11+/-0.18 (P<0.01) during the hyperacute phase (2 to 5 h), whereas rFA declined to 0.90+/-0.20 (P<0.01) and 0.88+/-0.12 (P<0.01) in the acute (7 to 14 h) and subacute (18 to 34 h) phases, respectively. Of those patients with lesions in major WM, 4 of 8 patients <or=7 h showed elevated rFA as opposed to none of the remaining 13 patients after 7 h. A greater proportion of the evaluated WM regions-of-interest (ROI) in the hyperacute phase revealed increases in rFA (60%), whereas conversely large proportions of ROIs (55% and 59%) in the acute and subacute phases showed reduced rFA. Similar anisotropy changes were noted in subcortical WM regions in the gyri.
Authors:
Yusuf A Bhagat; Derek J Emery; Ashfaq Shuaib; Faiz Sher; Nasir H Rizvi; Naveed Akhtar; Tracey L Clare; Tammy Leatherdale; Christian Beaulieu
Related Documents :
21990544 - Low-flow vascular malformations of the head and neck: clinicopathology and image guided...
21926864 - New spatiotemporal features for improved discrimination of benign and malignant lesions...
22211034 - Thyroglossal duct cyst-more than just an embryological remnant.
22079274 - Stereotactic biopsy with electrical monitoring for deep-seated brain tumors.
16498104 - Contrast-enhanced versus conventional and color doppler sonography for the detection of...
8861424 - Lesion width as a discriminator of plaque characteristics.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-22
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  26     ISSN:  0271-678X     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-24     Completed Date:  2006-11-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1442-50     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Anisotropy
Brain / pathology
Brain Ischemia / complications,  pathology
Diffusion Magnetic Resonance Imaging*
Female
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Stroke / etiology,  pathology*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Estimation of oxygen metabolism in a rat model of permanent ischemia using positron emission tomogra...
Next Document:  Deletions of 2q14 that include the homeobox engrailed 1 (EN1) transcription factor are compatible wi...