| The relationship between diet and subclinical atherosclerosis: results from the Asklepios Study. | |
| | |
MedLine Citation:
|
PMID: 21245883 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background/Objectives:Nutritional epidemiology shifted its focus from effects of single foods/nutrients toward the overall diet. Food-based dietary guidelines (FBDGs) are promoted worldwide to stimulate a healthy diet, including a variety of foods, to meet nutrient needs and to reduce the risk for non-communicable diseases. The objective of this study was to investigate whether adherence to the FBDG is associated with reduced femoral/carotid atherosclerosis and/or inflammation.Subjects/Methods:In October 2002, 2524 healthy men and women aged 35-55 years were recruited for the Belgian Asklepios cohort study. Subjects were extensively phenotyped, including echographic assessment of (carotid and femoral) atherosclerosis. A dietary index consisting of three subscores (dietary quality, diversity and equilibrium) was calculated to measure adherence to the Flemish FBDG, using data from a semi-quantitative food-frequency questionnaire. General linear models were used to investigate associations between these scores and cardiovascular (CV) risk factors and atherosclerosis and inflammation markers.Results:Women had better overall dietary scores than men (69 vs 59%). Participants with higher dietary scores showed better age-adjusted CV risk profiles (lower waist/hip ratio, blood pressure, non-high-density lipoprotein-cholesterol, blood triglycerides and homocystein), although most of these associations were only significant in men. Higher dietary scores were also inversely associated with inflammation makers (interleukin-6 and leukocyte count). Associations between diet and atherosclerosis were only found for femoral atherosclerosis and significance disappeared after adjustment for confounders.Conclusions:Better adherence to the Flemish FBDG is associated with a better CV risk profile and less inflammation, mainly among men. There was no direct effect on the presence of carotid or femoral atherosclerosis.European Journal of Clinical Nutrition advance online publication, 19 January 2011; doi:10.1038/ejcn.2010.286. |
| | |
Authors:
|
L I Hoebeeck; E R Rietzschel; M Langlois; M De Buyzere; D De Bacquer; G De Backer; L Maes; T Gillebert; I Huybrechts |
Related Documents
:
|
6121063 - High-density lipoprotein-cholesterol in marathon runners during a 20-day road race. 15238453 - Serum total and lipoprotein cholesterol levels and awareness, treatment, and control of... 2991173 - Dietary fibre intakes of individuals with different eating patterns. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-1-19 |
Journal Detail:
|
Title: European journal of clinical nutrition Volume: - ISSN: 1476-5640 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-1-19 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Public Health, Ghent University, Ghent, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A pilot randomized controlled trial of oral calcium and vitamin D supplementation using fortified la...
Next Document: Intake of antioxidants and risk of type 2 diabetes in a cohort of male smokers.