Document Detail

The relationship between coronary artery calcification detected by non-gated multi-detector CT in patients with suspected ischemic heart disease and myocardial ischemia detected by thallium exercise stress testing.
MedLine Citation:
PMID:  16444989     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine whether we could predict myocardial ischemia when coronary artery calcification is detected by non-gated multidetector CT in patients with suspected ischemic heart disease. METHODS: Eighty-three patients suspected of having ischemic heart disease (55 men, 28 women; age range 36-83 years; mean age 68 years) underwent multidetector CT and T1-201 single photon emission computed tomography. Prediction of myocardial ischemia by coronary arterial calcification detected on CT was evaluated by comparing the coronary artery territories that showed calcification with the area of myocardial ischemia determined by SPECT. The sensitivity, specificity, positive predictive value, and negative predictive value of multidetector CT for predicting myocardial ischemia were calculated. Coronary angiography was also examined and compared with multidetector CT. Risk factors, including hypertension, smoking, hyperlipidemia, diabetes, and family history, were compared for evidence of coronary artery calcification detected by multidetector CT and myocardial ischemia detected by thallium nuclear scans. RESULTS: For analysis by patients, the sensitivity, specificity, positive predictive value, and negative predictive value of coronary artery calcification for myocardial ischemia detection were 65, 63, 56, and 71%, respectively. Similarly, for analysis by coronary arterial territories, those values were 56, 77, 41 and 86%, respectively. Coronary stenosis on CAG was also related to the ischemia determined by SPECT and calcification on multidetector CT. Ischemia was better influenced by risk factors than was coronary arterial calcification. CONCLUSIONS: For analysis by coronary arterial territories, the specificity and negative predictive value of coronary arterial calcification seen by multidetector CT are relatively high.
Chikako Nishida; Kaoru Okajima; Takashi Kudo; Takashi Yamamoto; Ryuichi Hattori; Yasumasa Nishimura
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Annals of nuclear medicine     Volume:  19     ISSN:  0914-7187     ISO Abbreviation:  Ann Nucl Med     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-01-31     Completed Date:  2006-04-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8913398     Medline TA:  Ann Nucl Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  647-53     Citation Subset:  IM    
Department of Radiology, Nara Hospital, Kinki University School of Medicine, Otoda-cho 1248-1, Ikoma, Nara 630-0293, Japan.
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MeSH Terms
Aged, 80 and over
Calcinosis / diagnosis*,  epidemiology*
Coronary Artery Disease / diagnosis*,  epidemiology*
Exercise Test / statistics & numerical data
Middle Aged
Myocardial Ischemia / diagnosis*,  epidemiology*
Radiopharmaceuticals / diagnostic use
Reproducibility of Results
Risk Assessment / methods
Risk Factors
Sensitivity and Specificity
Statistics as Topic
Thallium / diagnostic use
Tomography, Emission-Computed, Single-Photon / statistics & numerical data
Tomography, X-Ray Computed / statistics & numerical data*
Reg. No./Substance:
0/Radiopharmaceuticals; 7440-28-0/Thallium; 7791-12-0/thallium chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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