Document Detail

The relationship between congenital malformations and preterm birth.
MedLine Citation:
PMID:  18052839     Owner:  NLM     Status:  MEDLINE    
AIMS: To investigate how congenital malformations (CM) are associated with preterm (PT) births. METHODS: A population cohort study analyzed data from the New York State Congenital Malformations Registry to look at live births from the Lower Hudson Valley Region from 2000-2003. ICD9 codes identified all cases and types of CM in addition to cases with multiple malformations. Subjects were categorized into one of three gestational age (GA) groups. Only cases with a known GA at birth were included. Poisson regression analysis established a risk ratio for children born with a CM of being born preterm. RESULTS: The PT birth rate was 11.2% and the CM rate 3%. Children with a CM were more likely to be born PT (RR: 2.20; CI: 2.01-2.40), moderately preterm (RR: 1.95; CI: 1.76-2.15), and very preterm (RR: 3.45; CI: 2.95-4.04) than term. This relationship was maintained for most organ systems and malformation types evaluated when checked individually. Being born with more than one CM increased the likelihood of being born PT (OR: 1.72; CI: 1.37-2.15). CONCLUSIONS: Congenital malformations in children have a significant impact upon the likelihood of being born PT, and contribute significantly to the degree of prematurity.
Jordan S Kase; Paul Visintainer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  35     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2007  
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  538-42     Citation Subset:  IM    
The Division of Newborn Medicine, Department of Pediatrics, New York Medical College, Regional Neonatal Intensive Care Unit of Maria Fareri Children's Hospital at Westchester Medical Center, NY 10595, USA.
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MeSH Terms
Cohort Studies
Congenital Abnormalities / epidemiology*
Gestational Age
Infant, Newborn
Infant, Premature, Diseases / epidemiology*
Premature Birth / epidemiology*

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