Document Detail

The relationship between the changes in plasma atrial natriuretic peptide and renin angiotensin contents and hemodynamics in pulmonary hypertensive rats.
MedLine Citation:
PMID:  1421360     Owner:  NLM     Status:  MEDLINE    
Pulmonary artery pressure (PAP) increased significantly in rats after hypobaric hypoxic exposure for 15 days (CH15) (P less than 0.001) and was maintained at the same level after prolonged hypoxic exposure for 40 days (CH40). There were no significant changes in carotid systolic and diastolic blood pressure in CH15 and CH40 rats. The contractility of the right and left ventricles of CH15 and CH40 rats showed no difference as compared with the control group. Plasma atrial natriuretic peptide (ANP) content in CH40 rats was obviously increased (P less than 0.001), while angiotensin II (AII) dropped markedly (P less than 0.05). Plasma renin activity was increased in both hypoxic groups (P less than 0.05 respectively). These results indicate that during chronic hypoxia, plasma ANP and the renin-angiotensin system (RAS) play an important role in the modulation of pulmonary as well as systemic hemodynamics. They may work cooperatively to limit the development of pulmonary hypertension and to maintain systemic blood pressure within the normal range.
Y Cai; Q Cai; X Zhou
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences     Volume:  7     ISSN:  1001-9294     ISO Abbreviation:  Chin. Med. Sci. J.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-12-22     Completed Date:  1992-12-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9112559     Medline TA:  Chin Med Sci J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  36-9     Citation Subset:  IM    
Institute of Basic Medical Sciences, CAMS, Beijing.
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MeSH Terms
Angiotensin II / blood*
Anoxia / complications
Atrial Natriuretic Factor / blood*
Hemodynamics / drug effects*
Hypertension, Pulmonary / blood*,  etiology
Rats, Inbred Strains
Renin / blood*
Renin-Angiotensin System / drug effects
Reg. No./Substance:
11128-99-7/Angiotensin II; 85637-73-6/Atrial Natriuretic Factor; EC

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