| The relationship between carotid sinus hypersensitivity, orthostatic hypotension, and vasovagal syncope: a case-control study. | |
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MedLine Citation:
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PMID: 18987128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Previous uncontrolled studies reported an overlap between carotid sinus hypersensitivity (CSH), vasovagal syncope (VVS), and orthostatic hypotension (OH). We conducted a case-control study evaluating this relationship in a large patient cohort. METHODS AND RESULTS: The electronically stored continuous electrocardiograph and blood pressure (BP) measurements for active stand and head-up tilt-table (HUT) tests of 302 consecutive patients investigated with carotid sinus massage (CSM) were analysed. Carotid sinus hypersensitivity was defined as >or=3 s asystole and/or systolic BP (SBP) drop of >or=50 mmHg during CSM. Orthostatic hypotension was defined as BP reductions of >or=20 mmHg systolic or of >or=10 mmHg diastolic, whereas VVS was diagnosed with a positive HUT test. There was no significant difference in the number of subjects with OH (57 vs. 55%; P = 0.778) or HUT-positive VVS (45 vs. 47%; P = 0.828) between cases with CSH and controls without CSH. Carotid sinus hypersensitivity subjects had significantly larger SBP reduction (P = 0.039) and longer time to nadir (P = 0.007) during active stand, and trends to vasodepressor (P = 0.071) and dysautonomic responses to HUT (P = 0.151). CONCLUSION: Carotid sinus hypersensitivity, OH, and VVS are common conditions affecting patients with syncope and falls which are likely to co-exist in such individuals. The differences in haemodynamic response patterns to active stand and HUT in CSH subjects could be the result of an age-associated delay in sympathetic responses. |
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Authors:
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Maw Pin Tan; Julia L Newton; Tom J Chadwick; Steve W Parry |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-05 |
Journal Detail:
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Title: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology Volume: 10 ISSN: 1532-2092 ISO Abbreviation: Europace Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-21 Completed Date: 2009-02-12 Revised Date: 2013-03-06 |
Medline Journal Info:
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Nlm Unique ID: 100883649 Medline TA: Europace Country: England |
Other Details:
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Languages: eng Pagination: 1400-5 Citation Subset: IM |
Affiliation:
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Institute for Ageing and Health, Wolfson Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Case-Control Studies Comorbidity Female Great Britain / epidemiology Humans Hypotension, Orthostatic / diagnosis, epidemiology* Incidence Male Middle Aged Risk Assessment / methods* Risk Factors Syncope / diagnosis, epidemiology* Syncope, Vasovagal / diagnosis, epidemiology* Tilt-Table Test / statistics & numerical data |
| Grant Support | |
ID/Acronym/Agency:
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RCP/DMT 1st Round (5)//The Dunhill Medical Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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