| The relationship between cardiac output and dynamic cerebral autoregulation in humans. | |
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MedLine Citation:
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PMID: 20689094 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebral autoregulation adjusts cerebrovascular resistance in the face of changing perfusion pressures to maintain relatively constant flow. Results from several studies suggest that cardiac output may also play a role. We tested the hypothesis that cerebral blood flow would autoregulate independent of changes in cardiac output. Transient systemic hypotension was induced by thigh-cuff deflation in 19 healthy volunteers (7 women) in both supine and seated positions. Mean arterial pressure (Finapres), cerebral blood flow (transcranial Doppler) in the anterior (ACA) and middle cerebral artery (MCA), beat-by-beat cardiac output (echocardiography), and end-tidal Pco(2) were measured. Autoregulation was assessed using the autoregulatory index (ARI) defined by Tiecks et al. (Tiecks FP, Lam AM, Aaslid R, Newell DW. Stroke 26: 1014-1019, 1995). Cerebral autoregulation was better in the supine position in both the ACA [supine ARI: 5.0 ± 0.21 (mean ± SE), seated ARI: 3.9 ± 0.4, P = 0.01] and MCA (supine ARI: 5.0 ± 0.2, seated ARI: 3.8 ± 0.3, P = 0.004). In contrast, cardiac output responses were not different between positions and did not correlate with cerebral blood flow ARIs. In addition, women had better autoregulation in the ACA (P = 0.046), but not the MCA, despite having the same cardiac output response. These data demonstrate cardiac output does not appear to affect the dynamic cerebral autoregulatory response to sudden hypotension in healthy controls, regardless of posture. These results also highlight the importance of considering sex when studying cerebral autoregulation. |
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Authors:
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B M Deegan; E R Devine; M C Geraghty; E Jones; G Ólaighin; J M Serrador |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-08-05 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 109 ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-09 Completed Date: 2011-02-18 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1424-31 Citation Subset: IM |
Affiliation:
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School of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anterior Cerebral Artery / physiopathology*, ultrasonography Blood Pressure Cardiac Output* Cerebrovascular Circulation* Echocardiography Electrocardiography Female Heart Rate Homeostasis Humans Hypotension / physiopathology*, ultrasonography Male Middle Cerebral Artery / physiopathology*, ultrasonography Photoplethysmography Regional Blood Flow Sex Factors Supine Position Thigh / blood supply* Time Factors Ultrasonography, Doppler, Transcranial Vascular Resistance Young Adult |
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