Document Detail


The relationship between bronchial hyperresponsiveness and lung function, in children age five and six with and without asthma.
MedLine Citation:
PMID:  23356445     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: It is unknown whether wheezy children have bronchial hyperresponsiveness (BHR), or which lung function parameters are correlated with BHR in children. We evaluated the relationship between BHR parameters and the lung functions by minimizing the effects of age and height in asthmatic, non-asthmatic wheezers and healthy children. METHODS: The subjects comprised of 154 children aged 5 and 6 years, (78 males, 76 females), who were divided into three groups: asthmatics, non-asthmatic wheezers and healthy controls. Spirometry and a methacholine inhalation challenge by the oscillation method were performed. RESULTS: The age of the study cohort was 5.9±0.2 years (mean±SD), and the height was 114.4±5.3 cm. No significant differences in height, weight, BMI or lung function was observed in the three groups. The minimal dose of methacholine (Dmin) to start bronchoconstriction, a parameter of bronchial sensitivity, was lower in asthmatics and non-asthmatic wheezers than that in controls. The speed of bronchoconstriction in response to methacholine (Sm), a parameter of bronchial reactivity, was strongly correlated with respiratory resistance (Rrs. cont) in all three groups. CONCLUSIONS: Our data suggest that it not possible to distinguish children with asthma from non-asthmatic wheezers based on their bronchial sensitivity. The baseline Rrs has a stong effect on the bronchial reactivity in children.
Authors:
Satoru Takami; Hiroyuki Mochizuki; Reiko Muramatsu; Satomi Hagiwara; Hirokazu Arakawa
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-28
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1843     ISO Abbreviation:  Respirology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology.
Affiliation:
Department of Pediatrics, Gunma University Graduate School of Medicine, Gunma, Japan; Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
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