| The relationship between blood pressure and cognitive function. | |
| | |
MedLine Citation:
|
PMID: 20978471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The relationship between blood pressure (BP) and cognitive outcomes in elderly adults has implications for global health care. Both hypertension and hypotension affect brain perfusion and worsen cognitive outcomes. The presence of hypertension and other vascular risk factors has been associated with decreased performance in executive function and attention tests. Cerebrovascular reserve has emerged as a potential biomarker for monitoring pressure-perfusion-cognition relationships. A decline in vascular reserve capacity can lead to impaired neurovascular coupling and decreased cognitive ability. Endothelial dysfunction, microvascular disease, and mascrovascular disease in midlife could also have an important role in the manifestations and severity of multiple medical conditions underlying cognitive decline late in life. However, questions remain about the role of antihypertensive therapies for long-term prevention of cognitive decline. In this Review, we address the underlying pathophysiology and the existing evidence supporting the role of vascular factors in late-life cognitive decline. |
| | |
Authors:
|
Vera Novak; Ihab Hajjar |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-10-26 |
Journal Detail:
|
Title: Nature reviews. Cardiology Volume: 7 ISSN: 1759-5010 ISO Abbreviation: Nat Rev Cardiol Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-24 Completed Date: 2011-03-21 Revised Date: 2012-04-20 |
Medline Journal Info:
|
Nlm Unique ID: 101500075 Medline TA: Nat Rev Cardiol Country: England |
Other Details:
|
Languages: eng Pagination: 686-98 Citation Subset: IM |
Affiliation:
|
Division of Gerontology, Beth Israel Deaconess Medical Center and Harvard Medical School, 110 Francis Street, LMOB Suite 1b, Boston, MA 02215, USA. vnovak@bidmc.harvard.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Aged Aged, 80 and over Antihypertensive Agents / therapeutic use Blood Pressure* / drug effects Cognition* / drug effects Cognition Disorders / drug therapy, etiology*, physiopathology, psychology Female Humans Hypertension / complications*, drug therapy, physiopathology, psychology Hypotension / complications*, physiopathology, psychology Male Middle Aged Risk Assessment Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
|
1P01AG028717-01A2/AG/NIA NIH HHS; 1R01AG028076-A2/AG/NIA NIH HHS; 1R21DK084463-01A1/DK/NIDDK NIH HHS; K23AG030057/AG/NIA NIH HHS; R01 AG028076-01A2/AG/NIA NIH HHS; R01 NS045745-04/NS/NINDS NIH HHS; R21 DK084463-02/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cardiovascular drug therapy in the elderly: benefits and challenges.
Next Document: Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis.