| The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients. | |
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MedLine Citation:
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PMID: 21975690 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Large-artery stiffness is a risk factor for stroke, including cerebral small-vessel disease. Retinal microvascular changes are thought to mirror those in cerebral microvessels. We investigated the relationship between aortic stiffness and retinal microvascular changes in Asian ischemic stroke patients. We studied 145 acute ischemic stroke patients in Singapore who had aortic stiffness measurements using carotid-femoral pulse wave velocity (cPWV). Retinal photographs were assessed for retinal microvessel caliber and qualitative signs of focal arteriolar narrowing, arteriovenous nicking and enhanced arteriolar light reflex. Aortic stiffening was associated with retinal arteriolar changes. Retinal arteriolar caliber decreased with increasing cPWV (r=-0.207, P=0.014). After adjusting for age, gender, hypertension, diabetes, mean arterial pressure and small-vessel stroke subtype, patients within the highest cPWV quartile were more likely to have generalized retinal arteriolar narrowing defined as lowest caliber tertile (odds ratio (OR) 6.84, 95% confidence interval (CI) 1.45-32.30), focal arteriolar narrowing (OR 13.85, CI 1.82-105.67), arteriovenous nicking (OR 5.08, CI 1.12-23.00) and enhanced arteriolar light reflex (OR 3.83, CI 0.89-16.48), compared with those within the lowest quartile. In ischemic stroke patients, aortic stiffening is associated with retinal arteriolar luminal narrowing as well as features of retinal arteriolosclerosis.Journal of Human Hypertension advance online publication, 6 October 2011; doi:10.1038/jhh.2011.88. |
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Authors:
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D A De Silva; F-P Woon; J J F Manzano; E Y Liu; H-M Chang; C Chen; J J Wang; P Mitchell; B A Kingwell; J D Cameron; R I Lindley; T Y Wong; M-C Wong |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-06 |
Journal Detail:
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Title: Journal of human hypertension Volume: - ISSN: 1476-5527 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8811625 Medline TA: J Hum Hypertens Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Singapore General Hospital Campus, National Neuroscience Institute, Singapore. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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