Document Detail

The relationship between aortic stiffness and cardiac function in patients with obstructive sleep apnea, independently from systemic hypertension.
MedLine Citation:
PMID:  17400115     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We sought to evaluate aortic function and its relationship with left ventricular (LV) function in patients with obstructive sleep apnea syndrome (OSAS), with or without systemic hypertension. METHODS: A total of 29 patients with OSAS, 28 patients with systemic hypertension without OSAS, and 19 patients having both disorders were chosen as a study group, and 29 participants without these two disorders were taken as the control group; none of the patients had a history of cardiac disease. All of them underwent echocardiography and polysomnography. Aortic strain and distensibility were calculated from the aortic diameters measured by echocardiography and blood pressure obtained by cuff-sphygmomanometer. Cardiac functions were determined using echocardiography comprising standard 2-dimensional and conventional Doppler and Doppler tissue imaging. RESULTS: Aortic strain (mean +/- SD; 6.1 +/- 2.7% vs 6.4 +/- 2.4%, 4.7 +/- 1.8%, and 13.7 +/- 4.5%, P < .001, respectively) and distensibility (mean +/- SD 2.8 +/- 1.6 vs 2.5 +/- 0.9, 1.7 +/- 0.7, and 6.2 +/- 3.2 10(-6) cm(2) dyn(-1)P < .001, respectively) were significantly decreased in the patient groups (OSAS, hypertensive, and OSAS and hypertensive) compared with the control group. LV long-axis and diastolic functions were also impaired in the study group. There were good correlations between the aortic stiffness and LV function parameters. In a multivariate analysis, aortic strain was the parameter found to be most strongly associated both with the Doppler tissue imaging mean peak early/late diastolic velocity ratio and the LV mitral lateral annular plane systolic excursion. CONCLUSION: Aortic stiffness parameters (aortic strain and distensibility), LV systolic long-axis function indicators (mitral lateral annular plane systolic excursion, peak systolic myocardial velocity at lateral annulus, peak systolic myocardial velocity at septal annulus), and Doppler tissue imaging-derived LV diastolic indices were found abnormal in patients with OSAS, hypertension, or both. Thus, subclinical cardiac dysfunction has been found in patients with OSAS independent from the systemic hypertension.
Yusuf Tavil; Asiye Kanbay; Nihat Sen; Tansu Ulukavak Ciftçi; Adnan Abaci; M Ridvan Yalçin; Oğuz Köktürk; Atiye Cengel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  20     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-02     Completed Date:  2007-06-05     Revised Date:  2007-11-02    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  366-72     Citation Subset:  IM    
Department of Cardiology, Gazi University Medical School, Ankara, Turkey. <>
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MeSH Terms
Aorta, Thoracic / physiopathology*,  ultrasonography
Blood Flow Velocity / physiology*
Blood Pressure / physiology
Echocardiography, Doppler / methods*
Follow-Up Studies
Hypertension / complications,  physiopathology*,  ultrasonography
Middle Aged
Myocardial Contraction / physiology*
Severity of Illness Index
Sleep Apnea, Obstructive / complications,  physiopathology*,  ultrasonography
Ventricular Function, Left / physiology*

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