Document Detail

The relationship between anti-cyclic citrullinated peptide and bone mineral density and radiographic damage in patients with rheumatoid arthritis.
MedLine Citation:
PMID:  18609264     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We aimed to investigate the relationship between anti-cyclic citrullinated peptide (anti-CCP) levels and bone mineral density (BMD), bone turnover, and radiographic damage in patients with rheumatoid arthritis (RA). METHODS: Eighty patients (68 females, 12 males, mean age 46.50+/-14.59 years) with RA were included in the study. Anti-CCP antibodies were measured by enzyme-linked immunosorbent assay (ELISA). Bone turnover was studied by analysing serum levels of C-terminal telopeptide of type I collagen (sCTX, ng/mL), using an enzyme immunoassay. BMD was measured by dual-energy X-ray absorptiometry (DXA). Disease activity was assessed according to the Disease Activity Score that includes 28 joint counts (DAS28). Functional capacity was assessed by the Health Assessment Questionnaire (HAQ). RESULTS: Anti-CCP-positive patients were defined as group 1 and anti-CCP-negative patients as group 2. The mean disease duration was 7.53+/-6.27 years in group 1 and 6.25+/-6.51 years in group 2. Anti-CCP had a limited negative correlation with lumbar BMD (r = -0.220, p = 0.050) and a negative correlation with femoral BMD (r = -0.242, p = 0.031). There was no statistically significant correlation between anti-CCP and sCTX values (r = 0.117, p = 0.301). Sharp scores were significantly higher in anti-CCP-positive than anti-CCP-negative patients (p = 0.012), and anti-CCP levels were significantly correlated with Sharp scores (r = 0.240, p = 0.032). CONCLUSIONS: We found that RA patients with higher levels of anti-CCP antibody had lower lumbar and femoral BMD. Anti-CCP levels were also associated with radiographic damage. Therefore, we suggest that anti-CCP may be a determinant of bone loss in patients with RA.
H Guler; A D Turhanoglu; B Ozer; C Ozer; A Balci
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Scandinavian journal of rheumatology     Volume:  37     ISSN:  1502-7732     ISO Abbreviation:  Scand. J. Rheumatol.     Publication Date:    2008 Sep-Oct
Date Detail:
Created Date:  2008-09-29     Completed Date:  2008-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0321213     Medline TA:  Scand J Rheumatol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  337-42     Citation Subset:  IM    
Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
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MeSH Terms
Absorptiometry, Photon
Antibodies, Anti-Idiotypic / blood*,  immunology
Arthritis, Rheumatoid / blood*,  physiopathology,  radiography*
Bone Density / physiology*
Collagen Type I / blood
Femur / metabolism,  physiopathology,  radiography
Lumbar Vertebrae / metabolism,  physiopathology,  radiography
Middle Aged
Osteoporosis / epidemiology,  physiopathology
Peptides / blood
Peptides, Cyclic / blood*,  immunology
Risk Factors
Severity of Illness Index
Reg. No./Substance:
0/Antibodies, Anti-Idiotypic; 0/Collagen Type I; 0/Peptides; 0/Peptides, Cyclic; 0/collagen type I trimeric cross-linked peptide; 0/cyclic citrullinated peptide

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