Document Detail

The relationship between anaerobic lactate threshold and plasma catecholamines during incremental exercise in hereditary spastic paraplegia.
MedLine Citation:
PMID:  12911138     Owner:  NLM     Status:  MEDLINE    
Lower limb muscle chronic hyperactivity in hereditary spastic paraplegia (HSP) is the consequence of motor corticospinal tract involvement, which in turn has been hypothesized to be of mitochondrial origin. In order to assess skeletal muscle aerobic metabolism and sympathetic response during exercise in 10 HSP patients, we evaluated their blood lactate and catecholamine levels during an incremental workload bicycle exercise. Lactate, but not epinephrine or norepinephrine, levels were significantly higher in the HSP patients than in control subjects, in both resting conditions and during exercise. In the patients, the anaerobic lactate threshold was reached prematurely (at 50% of the predicted normal maximal power output) when compared to normal controls. This finding was not related to any specific muscle morphology or histochemical activity. Although other factors, including chronic spasticity and muscle deconditioning, have to be considered in the interpretation of our data, our results suggest the possible involvement of a mitochondrial mechanism, independently of sympathetic system overactivation, in exercising skeletal muscle of HSP patients.
Gabriele Siciliano; Livia Pasquali; Maria Laura Manca; Alberto Del Corona; Alessandra Tessa; Clarice Patrono; Concetta Prontera; Giancarlo Zucchelli; Filippo M Santorelli
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Functional neurology     Volume:  18     ISSN:  0393-5264     ISO Abbreviation:  Funct. Neurol.     Publication Date:    2003 Apr-Jun
Date Detail:
Created Date:  2003-08-12     Completed Date:  2003-10-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8707746     Medline TA:  Funct Neurol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  83-7     Citation Subset:  IM    
Department of Neurosciences, Neurological Clinic, University of Pisa, Italy.
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MeSH Terms
Anaerobic Threshold / physiology
Epinephrine / blood*
Exercise Test
Lactates / blood*
Middle Aged
Models, Biological
Muscle, Skeletal / metabolism,  pathology
Norepinephrine / blood*
Physical Exertion / physiology*
Spastic Paraplegia, Hereditary / blood,  physiopathology*
Reg. No./Substance:
0/Lactates; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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