| The relationship between amniotic fluid levels of brain-type natriuretic peptide and recipient cardiomyopathy in twin-twin transfusion syndrome. | |
| | |
MedLine Citation:
|
PMID: 20719292 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: We sought to evaluate amniotic fluid brain natriuretic peptide (BNP) levels as a biomarker of recipient twin (RT) cardiomyopathy (RTCM) in twin-twin transfusion syndrome. STUDY DESIGN: Amniotic fluid samples were obtained from 157 twin-twin transfusion syndrome RTs and from 6 singletons (controls) from 2007 through 2009. N-terminal prohormone BNP (NT-proBNP) levels were quantified by enzyme-linked immunosorbent assay. RTCM was classified as mild (IIIA), moderate (IIIB), or severe (IIIC) by fetal echocardiography. The relationship between NT-proBNP and RTCM was evaluated using analysis of variance. The ability of NT-proBNP to predict moderate or greater RTCM was evaluated by receiver operating characteristic analysis. RESULTS: There is a significant positive correlation between NT-proBNP levels and worsening RTCM (r = 0.33; P < .001). NT-proBNP thresholds of 569 fmol/mg and 369 fmol/mg had a sensitivity of 70% and 87%, and specificity of 67% and 42%, respectively, in predicting moderate or greater RTCM. CONCLUSION: This is the first large case series that demonstrates a relationship between NT-proBNP and RTCM. This pathophysiologic insight supports ongoing efforts to develop screening biomarkers. |
| | |
Authors:
|
Mounira Habli; James Cnota; Erik Michelfelder; Shelia Salisbury; Beverly Schnell; William Polzin; Foong Yen Lim; Timothy M Crombleholme |
Publication Detail:
|
Type: Journal Article Date: 2010-08-16 |
Journal Detail:
|
Title: American journal of obstetrics and gynecology Volume: 203 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-29 Completed Date: 2010-11-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
|
Languages: eng Pagination: 404.e1-7 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2010 Mosby, Inc. All rights reserved. |
Affiliation:
|
Fetal Care Center of Cincinnati, Cincinnati Children's Hospital, Cincinnati, OH 45229-3039, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Amniotic Fluid / metabolism* Biological Markers / metabolism Blood Flow Velocity Cardiomyopathies / metabolism*, ultrasonography Case-Control Studies Enzyme-Linked Immunosorbent Assay Female Fetofetal Transfusion / metabolism* Humans Natriuretic Peptide, Brain / metabolism* Peptide Fragments / metabolism* Pregnancy ROC Curve Retrospective Studies Sensitivity and Specificity Severity of Illness Index Ultrasonography, Doppler Umbilical Veins / ultrasonography |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prediction of spontaneous preterm birth in asymptomatic twin pregnancies using the change in cervica...
Next Document: Beta 2 adrenergic agents and autism.