Document Detail

The relationship between aging and ribosomal gene activity in humans as evidenced by silver staining.
MedLine Citation:
PMID:  6168873     Owner:  NLM     Status:  MEDLINE    
Silver selectively stains nucleolar organizer regions (NORs) distributed on the D and G chromosomes of man. The number of NORs is fairly constant for a given individual but is highly variable within populations. When 2540 metaphases from lymphocytes were examined from 127 normal subjects, a mean NOR number of 7.3 was obtained with a mode of 7. No significant difference was found in mean NOR number between females and males. However, regression lines do show a decrease in NOR number with aging for both sexes but the rate of decline is more evident in females. Also, G chromosome NORs appear more stable than those in D chromosomes. Since silver--NOR staining is indicative of ribosomal gene activity, it is proposed that lymphocyte rDNA becomes less sensitive to phytohemagglutinin stimulation during aging. It is unique that this gene repression can be visualized with conventional staining and light microscopy.
T E Denton; S L Liem; K M Cheng; J V Barrett
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mechanisms of ageing and development     Volume:  15     ISSN:  0047-6374     ISO Abbreviation:  Mech. Ageing Dev.     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-11-19     Completed Date:  1981-11-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0347227     Medline TA:  Mech Ageing Dev     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
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MeSH Terms
Child, Preschool
Chromosomes / analysis*
Chromosomes, Human, 13-15
Chromosomes, Human, 21-22 and Y
Infant, Newborn
Lymphocytes / analysis
Middle Aged
Nucleolus Organizer Region / analysis*
Ribosomes / analysis*
Sex Factors
Staining and Labeling
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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