Document Detail


The relationship between aging and ribosomal gene activity in humans as evidenced by silver staining.
MedLine Citation:
PMID:  6168873     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Silver selectively stains nucleolar organizer regions (NORs) distributed on the D and G chromosomes of man. The number of NORs is fairly constant for a given individual but is highly variable within populations. When 2540 metaphases from lymphocytes were examined from 127 normal subjects, a mean NOR number of 7.3 was obtained with a mode of 7. No significant difference was found in mean NOR number between females and males. However, regression lines do show a decrease in NOR number with aging for both sexes but the rate of decline is more evident in females. Also, G chromosome NORs appear more stable than those in D chromosomes. Since silver--NOR staining is indicative of ribosomal gene activity, it is proposed that lymphocyte rDNA becomes less sensitive to phytohemagglutinin stimulation during aging. It is unique that this gene repression can be visualized with conventional staining and light microscopy.
Authors:
T E Denton; S L Liem; K M Cheng; J V Barrett
Related Documents :
23077533 - A consensus microsatellite-based linkage map for the hermaphroditic bay scallop (argope...
25207203 - Genetic mapping of fiber color genes on two brown cotton cultivars in xinjiang.
7551543 - Chromosomal evolution in bovids: a comparison of cattle, sheep and goat g- and r-banded...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mechanisms of ageing and development     Volume:  15     ISSN:  0047-6374     ISO Abbreviation:  Mech. Ageing Dev.     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-11-19     Completed Date:  1981-11-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0347227     Medline TA:  Mech Ageing Dev     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aging*
Child
Child, Preschool
Chromosomes / analysis*
Chromosomes, Human, 13-15
Chromosomes, Human, 21-22 and Y
Female
Humans
Infant
Infant, Newborn
Lymphocytes / analysis
Male
Middle Aged
Nucleolus Organizer Region / analysis*
Ribosomes / analysis*
Sex Factors
Silver
Staining and Labeling
Chemical
Reg. No./Substance:
7440-22-4/Silver

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The stimulus-induced release of unmetabolized 5-hydroxytryptamine from superfused rat brain synaptos...
Next Document:  Determination of amylase and lipase in peritoneal fluid: diagnostic value in ovarian cysts (author's...