Document Detail

The relationship between age-related heart rate changes and developing brain function: a model of anencephalic human fetuses in utero.
MedLine Citation:
PMID:  8200318     Owner:  NLM     Status:  MEDLINE    
We attempted to identify the brain segment which controls heart rate changes in human fetuses with advancing gestation. Twelve anencephalic and 165 normal fetuses (control-group fetuses) between 25-32 weeks' gestation were studied. The instantaneous fetal heart rate (FHR) data were obtained from each fetus for a continuous 90-120 min period, using an external cardiotocograph. Calculations included the 'individual probability distribution matrices' in which the FHRs at 1 beat/min intervals between 110 and 180 beats/min, the beat-to-beat differences (DFHRs) between +/- 5 beats/min and the probability values were arranged in rows, columns and the corresponding elements, respectively. Using 2-gestational-week intervals probability distribution matrices (age-group probability distribution matrices) obtained from 335 normal fetuses in our previous study as a reference, the difference between a given 'individual probability distribution matrix' and the corresponding age-group probability distribution matrix' was quantified as the 'difference rate' according to the formula in the text. From 25-26 to 27-28 weeks' gestation, the 'difference rates' in four anencephalic fetuses, with only the spinal cord preserved, were significantly higher in value than those of control-group fetuses, whereas the rates in four fetuses with both the spinal cord and medulla oblongata preserved, indicated no significant differences. From 29-30 to 31-32 weeks' gestation, the rates of the four fetuses with the spinal cord and medulla oblongata preserved, showed significant differences from the control-group fetuses. These findings suggest that there is a critical period between 27-28 and 29-30 weeks' gestation with regard to the developing brain function pertaining to FHR changes. In the early stage, the medulla oblongata plays a role in FHR changes, whereas, in the latter stage, the brain cephalad to the medulla also appears to take on the role of FHR regulator.
T Yoshizato; T Koyanagi; T Takashima; S Satoh; K Akazawa; H Nakano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Early human development     Volume:  36     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-07-07     Completed Date:  1994-07-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  101-12     Citation Subset:  IM    
Department of Gynecology and Obstetrics Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Anencephaly / embryology*,  physiopathology
Brain / embryology*,  physiology
Gestational Age
Heart Rate, Fetal / physiology*
Medulla Oblongata / embryology,  physiology
Spinal Cord / embryology,  physiology

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