| The relationship between adenoma weight and intact (1-84) parathyroid hormone level in primary hyperparathyroidism. | |
MedLine Citation:
|
PMID: 1539763 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The relationship between preoperative serum levels of intact parathyroid hormone (PTH), serum calcium, and the weight of parathyroid adenoma has been investigated in 44 patients undergoing surgery for primary hyperparathyroidism due to single gland disease. There was no significant correlation between preoperative serum calcium and either intact PTH concentration or adenoma weight (r = 0.465 and 0.381, respectively). Although there was a significant correlation between PTH concentration and adenoma weight (r = 0.850, p less than 0.0005), this correlation was lost when two unusually heavy adenomas weighing 10.98 and 15.23 g were removed from the analysis. Clearly, a preoperative direct prediction of gland weight determined from PTH level was not possible. Patients with adenomata heavier than 750 mg had a significantly lower circulating PTH level per mg of adenoma than patients with glands lighter than 750 mg. PTH secretion in vitro in low calcium medium by adenoma cells from glands weighing less than 1 g was higher than secretion by cells from adenomas heavier than 1 g. Larger parathyroid adenomata appear to secrete less PTH per unit weight in vivo and per unit cell in vitro under conditions of maximal stimulation. |
Authors:
|
J G Williams; M H Wheeler; J P Aston; R C Brown; J S Woodhead |
Related Documents
:
|
3862073 - Hypercalcemia in chronic myelogenous leukemia: evidence for excessive parathyroid hormo... 12771313 - Irma (whole pth) is a more useful assay for the effect of pth on bone than the allegro ... 17834373 - Nitrogen and potassium effect on the color of red roses. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of surgery Volume: 163 ISSN: 0002-9610 ISO Abbreviation: Am. J. Surg. Publication Date: 1992 Mar |
Date Detail:
|
Created Date: 1992-04-01 Completed Date: 1992-04-01 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0370473 Medline TA: Am J Surg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 301-4 Citation Subset: AIM; IM |
Affiliation:
|
Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenoma
/
blood,
complications,
pathology*,
surgery Adult Aged Calcium / blood Female Humans Hyperparathyroidism / blood*, etiology Male Middle Aged Parathyroid Hormone / blood* Parathyroid Neoplasms / blood, complications, pathology*, surgery |
| Chemical | |
Reg. No./Substance:
|
0/Parathyroid Hormone; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cystic metastases of the neck from occult thyroid adenocarcinoma.
Next Document: Stratified diagnostic approach to fine needle aspiration of the breast.