Document Detail


The relationship between adenoma weight and intact (1-84) parathyroid hormone level in primary hyperparathyroidism.
MedLine Citation:
PMID:  1539763     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relationship between preoperative serum levels of intact parathyroid hormone (PTH), serum calcium, and the weight of parathyroid adenoma has been investigated in 44 patients undergoing surgery for primary hyperparathyroidism due to single gland disease. There was no significant correlation between preoperative serum calcium and either intact PTH concentration or adenoma weight (r = 0.465 and 0.381, respectively). Although there was a significant correlation between PTH concentration and adenoma weight (r = 0.850, p less than 0.0005), this correlation was lost when two unusually heavy adenomas weighing 10.98 and 15.23 g were removed from the analysis. Clearly, a preoperative direct prediction of gland weight determined from PTH level was not possible. Patients with adenomata heavier than 750 mg had a significantly lower circulating PTH level per mg of adenoma than patients with glands lighter than 750 mg. PTH secretion in vitro in low calcium medium by adenoma cells from glands weighing less than 1 g was higher than secretion by cells from adenomas heavier than 1 g. Larger parathyroid adenomata appear to secrete less PTH per unit weight in vivo and per unit cell in vitro under conditions of maximal stimulation.
Authors:
J G Williams; M H Wheeler; J P Aston; R C Brown; J S Woodhead
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of surgery     Volume:  163     ISSN:  0002-9610     ISO Abbreviation:  Am. J. Surg.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-04-01     Completed Date:  1992-04-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  301-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adenoma / blood,  complications,  pathology*,  surgery
Adult
Aged
Calcium / blood
Female
Humans
Hyperparathyroidism / blood*,  etiology
Male
Middle Aged
Parathyroid Hormone / blood*
Parathyroid Neoplasms / blood,  complications,  pathology*,  surgery
Chemical
Reg. No./Substance:
0/Parathyroid Hormone; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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