| The relationship between the Trp 64 Arg polymorphism of the beta 3-adrenoceptor gene and idiopathic overactive bladder. | |
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MedLine Citation:
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PMID: 21529759 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to verify the association between the Trp 64 Arg polymorphism and idiopathic overactive bladder (OAB) syndrome. STUDY DESIGN: A case-control study was conducted with 218 women. The case group consisted of 49 patients with OAB symptoms; the control group included 169 women without urinary symptoms. The studied polymorphism was detected by restriction fragment length polymorphism analysis. The χ(2) test was used to compare categoric data, with a significance level of 5%. Numeric data were compared with the use of the parametric t test or nonparametric Mann-Whitney U test. RESULTS: The distribution of the polymorphism in the investigated women was digested homozygous T allele 69.75%, heterozygotes 29.8%, and homozygous A allele 0.45%. A comparison between the groups showed higher prevalence of the digested homozygous T allele genotype in women with OAB syndrome (P = .001). Multiple logistic regression analysis identified that a family history of OAB syndrome was an independent risk factor for OAB syndrome. CONCLUSION: The Trp 64 Arg polymorphism was associated with OAB syndrome in the Brazilian population. |
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Authors:
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Cristina E Ferreira; Andrea M Fonseca; Ismael D Silva; Manoel J Girão; Marair G Sartori; Rodrigo A Castro |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-23 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: - ISSN: 1097-6868 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-5-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
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Section of Urogynecology and Pelvic Surgery, Department of Gynecology, Federal University of São Paulo, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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