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The relationship between L-arginine/ADMA ratio and coronary collateral development in patients with low glomerular filtration rate.
MedLine Citation:
PMID:  22298165     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background: It is yet to be established which factors are responsible for differences among patients with the same degree of coronary artery disease in terms of coronary collateral development (CCD). Methods: Patients who had a greater than or equal to 95% stenosis in at least one epicardial coronary artery were classified into two groups according to their glomerular filtration rate (GFR) level. Afterwards, the degree of CCD was evaluated according to their plasma concentration of asymmetric dimethylarginine (ADMA) and GFR levels. Results: Rentrop grade 2-3 was found more frequently in patients with GFR 〉 60 mL/min than in patients with GFR 〈 60 mL/min (68.6% vs 41.4%, p = 0.032). Then we divided patients into four groups according to their GFR levels and Rentrop grades; whereas we did not find any significant difference for L-arginine or ADMA levels (respectively p = 0.629 and p = 0.076), we did find a statistically significant difference between groups for L-arginine/ /ADMA ratio (p = 0.003) and this statistically significant difference was evident between patients with GFR 〈 60 mL/min and Rentrop 0-1 and patients with GFR 〉 60 mL/min and Rentrop 2-3 (1.23 vs 1.69, p 〈 0.001). Multivariate logistic regression analysis revealed that L-arginine/ADMA ratio was the only variable which had a significant effect on CCD (OR = 1.016; 95% CI 1.001-1.031, Wald = 4.565; p = 0.033). Conclusions: These results showed that CCD was poor in patients with GFR 〈 60 mL/min, presumably because of the adverse effect of decreased L-arginine/ADMA ratio on endothelial cells and angiogenesis. (Cardiol J 2012; 19, 1: 29-35).
Authors:
Murat Celik; Atila Iyisoy; Turgay Celik; Mahmut Ilker Yilmaz; Uygar Cagdas Yuksel; Halil Yaman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology journal     Volume:  19     ISSN:  1897-5593     ISO Abbreviation:  Cardiol J     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  29-35     Citation Subset:  IM    
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