Document Detail

The relationship between DNA replication and chromosome structure.
MedLine Citation:
PMID:  66179     Owner:  NLM     Status:  MEDLINE    
The results obtained by acridine orange staining of chromosomes, after BrdU treatment, during one or two cell cycles, are described. The alterations of chromosome structure do not depend only on BrdU incorporation into DNA. Some other mechanisms are necessarily involved, and it is postulated that they are disturbances of protein-DNA association, occurring in G1 and in S- or G2-phase. The aspect of metaphase chromosomes then appears as the result of several metabolic steps, all occurring during interphase.
B Dutrillaux
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human genetics     Volume:  35     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-05-25     Completed Date:  1977-05-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  247-53     Citation Subset:  IM    
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MeSH Terms
Bromodeoxyuridine / pharmacology*
Chromatids / drug effects
Chromosomes / drug effects*
DNA Replication*
Staining and Labeling
Reg. No./Substance:
0/Acridines; 59-14-3/Bromodeoxyuridine

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