Document Detail


The relationship between CYP2C9 gene polymorphisms and upper gastrointestinal bleeding in patients who used warfarin.
MedLine Citation:
PMID:  23348161     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Aim Oral anticoagulants are the most common used substance for treatment and prophylaxis of warfarin venous and arterial thromboembolic disorders in the world. Therapeutic index of warfarin is narrow. CYP2C9 is a hepatic microsomal enzyme and has a primary role in metabolism of warfarin and genetic variations of CYP2C9 may cause a serious effect on the response to warfarin in patients. The aim of this study was to determine the eficiency of CYP2C9 gene polymorphisms on drug metabolism in patients who had upper gastrointestinal system bleeding while using warfarin. Methods There was a total of 67 patients in this study, 37 of whom had upper gastrointestinal system bleeding when INR was above 3 while using warfarin (group 1), 30 of whom had no bleeding and INR was stable under 3 (group 2). Results There was no difference in terms of warfarin dose used among the groups (p>0.05). Mutant genotype, INR and aspirin usage were found signiicantly different in the group with bleeding (p less 0.05). When analyzed in terms of drug interaction, there was no difference between the two groups (p>0.05). Logistic regression analysis was made in order to determine the risk factors that may cause bleeding. Aspirin usage (p= 0.016) and genetic polymorphism (p= 0.024) were related to the increased risk of bleeding. Conclusion CYP2C9*2 and CYP2C9*3 polymorphisms were related to the increase of excessive anticoagulation and bleeding risk in the patients who used warfarin.
Authors:
Mahmut Ucar; Hakan Alagozlu; Safak Sahin; Ozturk Ozdemir
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina     Volume:  10     ISSN:  1840-0132     ISO Abbreviation:  Med Glas Ljek komore Zenicko-doboj kantona     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101250177     Medline TA:  Med Glas Ljek komore Zenicko-doboj kantona     Country:  Bosnia and Hercegovina    
Other Details:
Languages:  eng     Pagination:  50-4     Citation Subset:  IM    
Affiliation:
1Internal Medicine, Sivas State Hospital, Sivas, 2Department of Internal Medicine, Gastroenterology, School of Medicine, Cumhuriyet University, Sivas, 3School of Medicine, Department of Internal Medicine, Gaziosmanpasa University, Tokat, 4Department of Medical Genetic, School of Medicine, Canakkale Onsekiz Mart University, Canakkale; Turkey.
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