Document Detail

The relationship between BMI and metabolomic profiles: a focus on amino acids.
MedLine Citation:
PMID:  22863201     Owner:  NLM     Status:  MEDLINE    
The role of metabolomics in the field of nutrition is continuing to grow and it has the potential to assist in the understanding of metabolic regulation and explain how minor perturbations can have a multitude of biochemical endpoints. It is this development, which creates the potential to provide the knowledge necessary to facilitate a more targeted approach to nutrition. In recent years, there has been interest in applying metabolomics to examine alterations in the metabolic profile according to weight gain/obesity. Emerging from these studies is the strong evidence that alterations in the amino acid (AA) profiles are associated with obesity. Several other studies have also shown a relationship between branched-chain amino acids (BCAA), obesity and insulin resistance. The present review focuses on the proposed link between AA and in particular BCAA, obesity and insulin resistance. In conclusion, a wealth of information is accumulating to support the role of AA, and in particular of the BCAA, in obesity.
Ciara Morris; Colm O'Grada; Miriam Ryan; Helen M Roche; Michael J Gibney; Eileen R Gibney; Lorraine Brennan
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-08-06
Journal Detail:
Title:  The Proceedings of the Nutrition Society     Volume:  71     ISSN:  1475-2719     ISO Abbreviation:  Proc Nutr Soc     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-26     Completed Date:  2013-04-04     Revised Date:  2013-04-24    
Medline Journal Info:
Nlm Unique ID:  7505881     Medline TA:  Proc Nutr Soc     Country:  England    
Other Details:
Languages:  eng     Pagination:  634-8     Citation Subset:  IM    
UCD Institute of Food and Health, University College Dublin, Belfield, Dublin 4, Republic of Ireland.
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MeSH Terms
Amino Acids / metabolism*
Amino Acids, Branched-Chain / metabolism
Body Mass Index*
Insulin Resistance*
Obesity / metabolism*
Reg. No./Substance:
0/Amino Acids; 0/Amino Acids, Branched-Chain

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