| The relationship between ASAT, CKMB, troponin-T and mortality after cardiac surgery. | |
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MedLine Citation:
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PMID: 17852782 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the relationship between ASAT, CKMB, troponin-T and mortality after cardiac surgery. DESIGN: ASAT, CKMB and TnT were analysed in 116 patients. Correlation, sensitivity, specificity and predictive values for permanent myocardial injury (defined as TnT > or = 2.0 microg/l postoperative day four) were calculated. In the second part our clinical protocol (ASAT on postoperative day 1 and TnT on day 3-4 in patients with ASAT above 2.5 microkat/l) was evaluated. Mortality was compared between patients with ASAT < 2.5 microkat/l (ASAT-), 2. ASAT > or = 2.5 microkat/l and TnT < 2.0 microg/l (ASAT+/TnT-) and 3. ASAT > or = 2.5 microkat/l and TnT > or = 2.0 microg/l (ASAT+/TnT+). RESULTS: Both ASAT and CKMB had irrespectively of cut-off level, low positive and high negative predictive value of permanent myocardial injury. Early and mid-term mortality did not differ significantly between ASAT- and ASAT+/TnT- patients. CONCLUSIONS: ASAT and CKMB can be used to exclude but not to diagnose permanent myocardial injury after cardiac surgery. Increased postoperative ASAT in the absence of increased TnT is not associated with worse clinical outcome than after normal postoperative ASAT. |
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Authors:
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Anna Sellgren; Folke Nilsson; Anders Jeppsson |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian cardiovascular journal : SCJ Volume: 41 ISSN: 1401-7431 ISO Abbreviation: Scand. Cardiovasc. J. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2008-05-23 Completed Date: 2008-06-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708377 Medline TA: Scand Cardiovasc J Country: England |
Other Details:
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Languages: eng Pagination: 386-90 Citation Subset: IM |
Affiliation:
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Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Göteborg, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aspartate Aminotransferases / blood* Biological Markers / blood* Cardiac Surgical Procedures / mortality* Creatine Kinase, MB Form / blood* Female Heart Diseases / surgery Humans Male Middle Aged Myocardial Ischemia / blood, pathology Myocardium / pathology* Postoperative Period Retrospective Studies Sensitivity and Specificity Troponin T |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Troponin T; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.7.3.2/Creatine Kinase, MB Form |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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