Document Detail


The relationship between ASAT, CKMB, troponin-T and mortality after cardiac surgery.
MedLine Citation:
PMID:  17852782     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the relationship between ASAT, CKMB, troponin-T and mortality after cardiac surgery. DESIGN: ASAT, CKMB and TnT were analysed in 116 patients. Correlation, sensitivity, specificity and predictive values for permanent myocardial injury (defined as TnT > or = 2.0 microg/l postoperative day four) were calculated. In the second part our clinical protocol (ASAT on postoperative day 1 and TnT on day 3-4 in patients with ASAT above 2.5 microkat/l) was evaluated. Mortality was compared between patients with ASAT < 2.5 microkat/l (ASAT-), 2. ASAT > or = 2.5 microkat/l and TnT < 2.0 microg/l (ASAT+/TnT-) and 3. ASAT > or = 2.5 microkat/l and TnT > or = 2.0 microg/l (ASAT+/TnT+). RESULTS: Both ASAT and CKMB had irrespectively of cut-off level, low positive and high negative predictive value of permanent myocardial injury. Early and mid-term mortality did not differ significantly between ASAT- and ASAT+/TnT- patients. CONCLUSIONS: ASAT and CKMB can be used to exclude but not to diagnose permanent myocardial injury after cardiac surgery. Increased postoperative ASAT in the absence of increased TnT is not associated with worse clinical outcome than after normal postoperative ASAT.
Authors:
Anna Sellgren; Folke Nilsson; Anders Jeppsson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian cardiovascular journal : SCJ     Volume:  41     ISSN:  1401-7431     ISO Abbreviation:  Scand. Cardiovasc. J.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-05-23     Completed Date:  2008-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708377     Medline TA:  Scand Cardiovasc J     Country:  England    
Other Details:
Languages:  eng     Pagination:  386-90     Citation Subset:  IM    
Affiliation:
Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Göteborg, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aspartate Aminotransferases / blood*
Biological Markers / blood*
Cardiac Surgical Procedures / mortality*
Creatine Kinase, MB Form / blood*
Female
Heart Diseases / surgery
Humans
Male
Middle Aged
Myocardial Ischemia / blood,  pathology
Myocardium / pathology*
Postoperative Period
Retrospective Studies
Sensitivity and Specificity
Troponin T
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Troponin T; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.7.3.2/Creatine Kinase, MB Form

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