Document Detail

The relationship among brain, spinal cord and anesthetic requirements.
MedLine Citation:
PMID:  9049994     Owner:  NLM     Status:  MEDLINE    
The spinal cord is a crucial site wherein anesthetics suppress movement in response to noxious stimuli. The balance of excitatory and inhibitory influences on the spinal cord likely determines the extent of motor response, and is thus important to anesthetic requirements. When the volatile anesthetic isoflurane is selectively delivered to the in situ goat brain (with low concentrations in the torso), anesthetic requirements increase dramatically, but when low isoflurane concentrations are delivered to the brain, anesthetic requirements decrease in the torso. When high, supraclinical concentrations of isoflurane (6-10%) are delivered to the brain and not to the torso, spontaneous movement occurs. These results are best explained by a differential effect of anesthetics on spinal cord neurons and cerebral neurons (midbrain reticular formation). Examination of neurons in the dorsal horn and midbrain reticular formation, and the electromyogram, during differential delivery of isoflurane to brain and spinal cord, will test this hypothesis.
J F Antognini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  48     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-05-12     Completed Date:  1997-05-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  83-7     Citation Subset:  IM    
Department of Anesthesiology, University of California, Davis 95616, USA.
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MeSH Terms
Anesthesia, General*
Anesthetics, Inhalation / administration & dosage,  pharmacology
Brain / drug effects,  physiology*
Isoflurane / administration & dosage,  pharmacology*
Models, Neurological
Motor Activity
Neurons / drug effects,  physiology*
Spinal Cord / drug effects,  physiology*
Reg. No./Substance:
0/Anesthetics, Inhalation; 26675-46-7/Isoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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