Document Detail

The relations of microalbuminuria to ambulatory blood pressure and myocardial wall thickness in a population.
MedLine Citation:
PMID:  9698025     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To examine the relationship between microalbuminuria (20-200 microg min(-1)) and 24 h ambulatory blood pressure and heart wall thickness, in a representative population sample of men and women aged 56-65 years. DESIGN: Every second individual aged 56-65 years (n=488) in the district, was invited for a health examination, which included determination of urinary albumin and creatinine (overnight sample). The highest and lowest decentile of urinary albumin/creatinine ratio were compared. SETTING: The district of the Primary Health Care and Research Centre of Mölnlycke, Sweden. SUBJECTS: After excluding 2 individuals with a urinary albumin excretion exceeding 200 microg min(-1). 26 subjects (group 1) could be compared with 27 subjects in the lowest decentile (group 2). MAIN OUTCOME MEASURES: Comparison between the determinations of the ambulatory blood pressure and echocardiographic variables in the two groups. RESULTS: Group 1 had significantly higher 24 h ambulatory blood pressure, and heart septum and posterior wall thickness as well as significantly higher fasting blood glucose and serum triglyceride concentrations. The differences in blood pressure (P < 0.05) but not heart wall thickness remained significant (P<0.05) after excluding subjects with hypertension, angina pectoris, treated diabetes mellitus, and/or history of heart or cerebrovascular disease. When excluding individuals with both treated and untreated diabetes mellitus, fasting blood glucose concentration was higher in group 1. The waist-hip ratio, weight and body mass index did not differ between the groups. CONCLUSIONS: The findings indicate that microalbuminuria is related to signs of cardiovascular and metabolic influence and therefore could be a valuable tool for grading the risk of later cardiovascular morbidity.
T Nilsson; A Svensson; L Lapidus; G Lindstedt; E Nyström; R Eggertsen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of internal medicine     Volume:  244     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-08-25     Completed Date:  1998-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  55-9     Citation Subset:  IM    
Department of Primary Health Care, Mölnlycke Primary Health Care and Research Centre, Göteberg, Sweden.
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MeSH Terms
Albuminuria* / classification,  complications,  metabolism
Blood Glucose
Blood Pressure*
Body Mass Index
Cardiovascular Diseases / etiology*
Creatinine / urine
Middle Aged
Myocardium / pathology*
Population Surveillance / methods*
Risk Factors
Triglycerides / blood
Reg. No./Substance:
0/Blood Glucose; 0/Triglycerides; 60-27-5/Creatinine

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