Document Detail

The relation of vitamin D deficiency with puberty and insulin resistance in obese children and adolescents.
MedLine Citation:
PMID:  22570955     Owner:  NLM     Status:  MEDLINE    
The prevalence of obesity among children and adolescents has been rapidly increasing in recent years. Obese individuals are at risk for vitamin D deficiency. The aim of this study was to investigate the relation of vitamin D deficiency with puberty and insulin resistance in obese children and adolescents. A total of 106 children and adolescents (48 prepubertal and 58 pubertal) between 8 and 16 years of age were included in the study. Fasting blood glucose, insulin, lipid profile, calcium, phosphorus, alkaline phosphatase, parathyroid hormone, 25-hydroxyvitamin D [25(OH)D] levels, as well as blood glucose and insulin concentrations at 120 min of oral glucose tolerance test were measured. Insulin resistance was calculated using the homeostasis model assessment. Daily vitamin D intake was questioned. Serum 25(OH)D level was normal in only 3.8%, insufficient in 34.0%, and deficient in 62.2% of the subjects. There was a statistically significant rate of 25(OH)D deficiency in the pubertal group compared with that in the prepubertal group. Those subjects with 25(OH)D deficiency were found to have greater insulin resistance. Vitamin D deficiency is common among obese children and adolescents. Low vitamin D levels in obese individuals may accelerate the development of metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease by further increasing insulin resistance.
Muammer Buyukinan; Samim Ozen; Serap Kokkun; Eylem Ulas Saz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  25     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-10     Completed Date:  2012-05-31     Revised Date:  2013-03-20    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  83-7     Citation Subset:  IM    
Department of Pediatric Endocrinology, Dr. Behcet Uz Children's Training and Research Hospital, 35020 Izmir, Turkey.
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MeSH Terms
Insulin Resistance*
Metabolic Syndrome X / etiology*
Obesity / complications*
Puberty / metabolism*
Vitamin D Deficiency / complications*
Comment In:
J Pediatr Endocrinol Metab. 2012;25(9-10):1043-4   [PMID:  23426842 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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