Document Detail

The relation of testosterone levels with fatigue and apathy in Parkinson's disease.
MedLine Citation:
PMID:  19131155     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Fatigue and apathy are frequent in patients with Parkinson's disease (PD). Testosterone deficiency in male patients may contribute in development of fatigue and apathy as well. We investigated whether a possible relation exists between serum testosterone levels, fatigue and apathy in male PD patients. MATERIALS AND METHODS: We included 29 non-demented and non-depressed PD patients and 30 age- and sex-matched healthy subjects. Fatigue Severity Scale (FSS) and Apathy Evaluation Scale (AES-C) were used for the evaluations. In PD patients and healthy subjects, a relationship between FSS, AES-C scores and plasma testosterone levels were assessed. In addition, a correlation between FSS, AES-C and Unified Parkinson's Disease Rating Scale was investigated in PD group. RESULTS: The mean scores of FSS and AES-C were significantly higher in PD patients than those of the control group. The Unified Parkinson's Disease Rating Scale (UPDRS) scores were significantly correlated with FSS and AES-C scores. Mean free testosterone level was significantly lower in PD patients than controls (p=0.008). f-Testosterone levels of PD patients were not correlated with FSS or AES-C scores. CONCLUSION: Apathy and fatigue are frequent in PD and show significant correlation with the severity of the disease. f-Testosterone levels are not related with apathy or fatigue in male PD patients and the role of testosterone in the pathophysiology of these non-motor symptoms is still controversial.
Gülay Kenangil; Dilek Necioglu Orken; Emel Ur; Hulki Forta; Munevver Celik
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Publication Detail:
Type:  Journal Article     Date:  2009-01-08
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  111     ISSN:  1872-6968     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-12     Completed Date:  2009-07-15     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  412-4     Citation Subset:  IM    
Department of Neurology, Education and Research Hospital of Sisli Etfal, Istanbul, Turkey.
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MeSH Terms
Activities of Daily Living
Aged, 80 and over
Antiparkinson Agents / therapeutic use
Fatigue / blood*,  etiology*
Levodopa / therapeutic use
Middle Aged
Parkinson Disease / blood*,  complications,  psychology*
Severity of Illness Index
Testosterone / blood*
Reg. No./Substance:
0/Antiparkinson Agents; 0/Levodopa; 58-22-0/Testosterone

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