Document Detail


The relation of soluble lead to toxicity: an in vitro analysis.
MedLine Citation:
PMID:  1139739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cells of human origin maintained in vitro in a phosphate-free medium (PFM) remain viable for over 24 h but lose viability rapidly in the presence of soluble lead. The threshold for this loss of viability is less than 1 ppm. In the presence of Ca-2+ in high concentrations, the cells maintain their viability. These data suggest that soluble lead is far more toxic than particulate lead, and that the protective action of the Ca-2+ ion in lead toxicity is not on a specific cell type.
Authors:
J Lipetz; O B Douglass
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemico-biological interactions     Volume:  11     ISSN:  0009-2797     ISO Abbreviation:  Chem. Biol. Interact.     Publication Date:  1975 Aug 
Date Detail:
Created Date:  1975-09-24     Completed Date:  1975-09-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0227276     Medline TA:  Chem Biol Interact     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  117-22     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amniotic Fluid / drug effects*
Calcium / pharmacology
Cell Survival / drug effects
Cells, Cultured / drug effects*
Dose-Response Relationship, Drug
Female
Humans
Lead / toxicity*
Pregnancy
Solubility
Time Factors
Chemical
Reg. No./Substance:
7439-92-1/Lead; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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