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The relation of serum gamma-glutamyl transferase levels with coronary lesion complexity and long-term outcome in patients with stable coronary artery disease.
MedLine Citation:
PMID:  22369933     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Relation of serum gamma-glutamyl transferase (GGT) levels with extent, severity, and complexity of coronary artery disease has not been adequately studied. Therefore, we evaluated the relationship between GGT levels and coronary complexity, severity and extent assessed by SYNTAX score and long-term adverse events. METHODS: We enrolled 442 consecutive patients with stable angina pectoris who underwent coronary angiography. Baseline serum GGT levels were measured and SYNTAX score was calculated from the study population. Median follow-up duration was 363 days. Endpoints were all cause mortality and any revascularization. RESULTS: GGT levels demonstrated an increase from low SYNTAX tertile to high tertile. In multivariate analysis serum GGT, diabetes mellitus, HDL-cholesterol, eGFR and ejection fraction were found to be independent predictors of high SYNTAX score. The survival analysis showed that long-term revascularization rates were comparable between the GGT groups (for 36U/l cut point) of the overall population (7.7% vs 8.6% logrank, p=0.577), whereas long-term all cause mortality rate was higher in the GGT≥36U/l group (3.6% vs 11.6% logrank, p=0.001). In Cox proportional hazards regression model, GGT≥36U/l group was found to be an independent predictor of long-term all cause mortality in the unadjusted (HR 2.54, 95% CI 1.17-5.48, p=0.018) and age- and gender-adjusted (HR 2.58, 95% CI 1.19-5.58, p=0.016) models. CONCLUSION: Serum GGT level was independently associated with coronary complexity and long-term mortality in patients with stable coronary artery disease.
Authors:
Enbiya Aksakal; Ibrahim Halil Tanboga; Mustafa Kurt; Mehmet Ali Kaygın; Ahmet Kaya; Turgay Isik; Mehmet Ekinci; Serdar Sevimli; Mahmut Acikel
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-3
Journal Detail:
Title:  Atherosclerosis     Volume:  -     ISSN:  1879-1484     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Ataturk University Medical School, Department of Cardiology, Erzurum, Turkey.
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