Document Detail


The relation of rhodopsin and scotopic retinal sensitivity in sector retinitis pigmentosa.
MedLine Citation:
PMID:  3341429     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We used reflection retinal densitometric, psychophysical, and electroretinographic techniques to study the scotopic retinal function of a mother and her three daughters who had clinical evidence of a sectoral type of retinitis pigmentosa. Retinal regions with, and those without, ophthalmoscopic signs of degeneration were investigated. During dark adaptation, the time courses of rhodopsin regeneration and recovery of scotopic sensitivity were similar to normal as was the relation of rhodopsin to scotopic threshold. In dark-adapted eyes, threshold increases were not proportional to rhodopsin loss. The results of psychophysical tests of background adaptation and temporal summation, and analysis of the relation of electroretinographic a- to b-wave amplitudes, led to the conclusion that abnormalities of photoreceptor cell function central to the rhodopsin-bearing outer segments accounted for the increased thresholds.
Authors:
A B Fulton; R M Hansen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  105     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-03-09     Completed Date:  1988-03-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  132-40     Citation Subset:  AIM; IM    
Affiliation:
Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
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MeSH Terms
Descriptor/Qualifier:
Adult
Dark Adaptation*
Densitometry
Electroretinography
Female
Humans
Ophthalmoscopy
Perimetry
Photoreceptor Cells / physiopathology
Regeneration
Retina / physiopathology*
Retinal Degeneration / physiopathology
Retinal Pigments / physiology*
Retinitis Pigmentosa / diagnosis,  genetics*,  physiopathology
Rhodopsin / physiology*
Grant Support
ID/Acronym/Agency:
EY 05329/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Retinal Pigments; 9009-81-8/Rhodopsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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