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The relation between the omega-3 index and arachidonic acid is bell shaped: Synergistic at low EPA+DHA status and antagonistic at high EPA+DHA status.
MedLine Citation:
PMID:  21715149     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: The relation between docosahexaenoic (DHA) and eicosapentaenoic (EPA) vs. arachidonic acid (AA) seems characterized by both synergism and antagonism. MATERIALS AND METHODS: Investigate the relation between EPA+DHA and AA in populations with a wide range of EPA+DHA status and across the life cycle. EPA+DHA and AA were determined in erythrocytes (RBC; n=1979), umbilical arteries (UA; n=789) and umbilical veins (UV; n=785). RESULTS: In all compartments, notably RBC, the relation between EPA+DHA and AA appeared bell-shaped. Populations with low RBC-EPA+DHA (<2g%) exhibited positive relationships; those with high RBC-EPA+DHA (>8g%) negative relationships. Antagonism in UA and UV could not be demonstrated. CONCLUSION: Both synergism and antagonism might aim at a balance between ω6 and ω3 long-chain polyunsaturated fatty acid (LCP) to maintain homeostasis. Synergism might be a feature of low LCPω3 status. AA becomes suppressed by antagonism from an RBC-EPA+DHA >8g%.
Authors:
Martine F Luxwolda; Remko S Kuipers; Ella N Smit; Francien V Velzing-Aarts; D A Janneke Dijck-Brouwer; Frits A J Muskiet
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-27
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  -     ISSN:  1532-2823     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Laboratory Medicine, University Medical Center Groningen (UMCG), 9700 RB Groningen, The Netherlands.
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