| The relation between immunoglobulin G antibodies to Chlamydia trachomatis and poor ovarian response to gonadotropin stimulation before in vitro fertilization. | |
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MedLine Citation:
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PMID: 9696209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether a relation exists between previous exposure to Chlamydia trachomatis and impaired ovarian response to gonadotropin stimulation. DESIGN: Controlled clinical study. SETTING: Two university IVF centers. PATIENT(S): Two hundred forty-two patients receiving IVF treatment and 81 control patients. Ninety-four patients with a poor response to IVF, defined by cycle cancellation in response to a daily stimulation dose of 300 IU of FSH, and 148 patients with a good response were matched for age. Twenty-eight pregnant controls and 53 controls of proven fertility also were included. INTERVENTION(S): Serum samples were obtained from patients and controls. Serum levels of immunoglobulin (Ig) G antibodies to C. trachomatis were determined by ELISA. MAIN OUTCOME MEASURE(S): The prevalence of serum IgG antibodies to C. trachomatis in critically defined poor responders was compared with that of age-matched good responders. RESULT(S): A significantly higher proportion of poor responders had serum IgG antibodies to C. trachomatis compared with good responders (44.7% and 30.4%, respectively). Patients undergoing IVF had a significantly higher prevalence of IgG antibodies to C. trachomatis (36%) than did either pregnant or nonpregnant controls (12%). CONCLUSION(S): A significantly higher prevalence of serum IgG antibodies to C. trachomatis was observed in critically defined poor responders, suggesting a possible detrimental effect of C. trachomatis on subsequent ovarian function. |
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Authors:
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S D Keay; R Barlow; A Eley; G M Masson; F W Anthony; J M Jenkins |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Multicenter Study |
Journal Detail:
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Title: Fertility and sterility Volume: 70 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-08-27 Completed Date: 1998-08-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 214-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, St. Michael's Hospital, University of Bristol, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Bacterial / blood* Chlamydia trachomatis / immunology* Female Fertilization in Vitro* Humans Immunoglobulin G / blood* Menotropins / therapeutic use* Ovary / drug effects*, immunology Pregnancy Stimulation, Chemical Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Immunoglobulin G; 61489-71-2/Menotropins |
| Comments/Corrections | |
Comment In:
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Fertil Steril. 1999 Feb;71(2):388-9
[PMID:
9988421
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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