Document Detail

The relation between immunoglobulin G antibodies to Chlamydia trachomatis and poor ovarian response to gonadotropin stimulation before in vitro fertilization.
MedLine Citation:
PMID:  9696209     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether a relation exists between previous exposure to Chlamydia trachomatis and impaired ovarian response to gonadotropin stimulation. DESIGN: Controlled clinical study. SETTING: Two university IVF centers. PATIENT(S): Two hundred forty-two patients receiving IVF treatment and 81 control patients. Ninety-four patients with a poor response to IVF, defined by cycle cancellation in response to a daily stimulation dose of 300 IU of FSH, and 148 patients with a good response were matched for age. Twenty-eight pregnant controls and 53 controls of proven fertility also were included. INTERVENTION(S): Serum samples were obtained from patients and controls. Serum levels of immunoglobulin (Ig) G antibodies to C. trachomatis were determined by ELISA. MAIN OUTCOME MEASURE(S): The prevalence of serum IgG antibodies to C. trachomatis in critically defined poor responders was compared with that of age-matched good responders. RESULT(S): A significantly higher proportion of poor responders had serum IgG antibodies to C. trachomatis compared with good responders (44.7% and 30.4%, respectively). Patients undergoing IVF had a significantly higher prevalence of IgG antibodies to C. trachomatis (36%) than did either pregnant or nonpregnant controls (12%). CONCLUSION(S): A significantly higher prevalence of serum IgG antibodies to C. trachomatis was observed in critically defined poor responders, suggesting a possible detrimental effect of C. trachomatis on subsequent ovarian function.
S D Keay; R Barlow; A Eley; G M Masson; F W Anthony; J M Jenkins
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Fertility and sterility     Volume:  70     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-08-27     Completed Date:  1998-08-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  214-8     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, St. Michael's Hospital, University of Bristol, United Kingdom.
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MeSH Terms
Antibodies, Bacterial / blood*
Chlamydia trachomatis / immunology*
Fertilization in Vitro*
Immunoglobulin G / blood*
Menotropins / therapeutic use*
Ovary / drug effects*,  immunology
Stimulation, Chemical
Treatment Outcome
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Immunoglobulin G; 61489-71-2/Menotropins
Comment In:
Fertil Steril. 1999 Feb;71(2):388-9   [PMID:  9988421 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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