Document Detail

The relation between electrocardiographic ST-T changes and NT-proBNP in patients with acute ischemic stroke.
MedLine Citation:
PMID:  17886116     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: ST-segment depression and T-wave inversion (ST-T changes) in the electrocardiogram (ECG) and raised levels of natriuretic peptide have been observed in acute ischemic stroke patients. It is unknown whether any relation between ST-T changes and raised levels of natriuretic peptides in patients with an acute ischemic stroke exists. METHODS: Serial measurements of plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and 12-lead ECGs were obtained in 192 consecutive patients with an acute ischemic stroke without ischemic heart disease, atrial fibrillation, heart- or renal failure. RESULTS: ST-T changes suggestive of myocardial ischemia were observed in the 12 lead ECG of 47 patients (24%). In uni- and multivariate regression analysis after adjustment for age, stroke severity, female sex, systolic blood pressure, diabetes mellitus, and levels of troponin T > 0.03 microg/L, ST-T changes in the ECG remained associated with increased levels of NT-proBNP (beta=76.5, p=0.011). CONCLUSIONS: ST-T changes suggestive of myocardial ischemia are independently associated with the levels of NT-proBNP in patients with acute ischemic stroke. The clinical importance of this observation remains to be defined.
Jesper K Jensen; Lars Korsholm; Poul Flemming Høilund-Carlsen; Dan Atar; Søren R Kristensen; Hans Mickley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian cardiovascular journal : SCJ     Volume:  41     ISSN:  1401-7431     ISO Abbreviation:  Scand. Cardiovasc. J.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-21     Completed Date:  2008-02-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708377     Medline TA:  Scand Cardiovasc J     Country:  England    
Other Details:
Languages:  eng     Pagination:  294-8     Citation Subset:  IM    
Department of Cardiology, Odense University Hospital, Denmark.
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MeSH Terms
Acute Disease
Biological Markers / blood
Brain Ischemia / diagnosis*,  physiopathology
Electrocardiography / instrumentation*,  methods
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Prospective Studies
Severity of Illness Index
Stroke / diagnosis*,  physiopathology
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

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