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The relation between dietary habits and urinary levels of 3-phenoxy benzoic acid, a pyrethroids metabolite.
MedLine Citation:
PMID:  23146693     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Concerns about pesticide exposure through food consumption have increased during the past several years. Pyrethroids are applied as insecticides throughout the world. Human metabolism of pyrethroids results in urinary metabolites that are suitable for biological monitoring. The objective of our study was to investigate the relation between food consumption and urinary levels of 3-phenoxybenzoic acid (3-PBA), a general metabolite of pyrethroids, in a non-occupational exposed adult population from the IDI-IRCCS, Rome, Italy. Information on socio-demographic characteristics, smoking, diet and self-reported household pesticide exposure was collected. Urinary 3-PBA level of each subject was measured and adjusted by urinary creatinine. We found that people consuming both raw and cooked vegetables five times weekly or more had higher mean levels of 3-PBA in urine (1.03 μg/g creatinine versus 0.52 μg/g creatinine; p=0.009 and 0.99 μg/g creatinine versus 0.58 μg/g creatinine; p=0.01 respectively) than subjects consuming less than five times weekly. In a multivariate model, after adjusting for age, sex, BMI, smoking and household insecticide exposure, high intake of raw vegetables (OR: 5.31; 95%CI: 1.32- 21.3) and high intake of cooked vegetables, in particular cruciferous (OR: 4.67; 95%CI: 1.07- 20.5) and leafy vegetables (OR: 6.88; 95%CI: 1.50- 31.7), were associated with high urine 3-PBA levels (⩾ 0.70. μg/g creatinine). The results of this study suggest that part of the variation in pyrethrois intake is explained by vegetable intake.
Authors:
C Fortes; S Mastroeni; M A Pilla; G Antonelli; L Lunghini; C Aprea
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-9
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  -     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome, Italy. Electronic address: c.fortes@idi.it.
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